TLDR Hair follicles in mutant mice self-organize into ordered patterns within a week.
The study investigated hair pattern development in frizzled 6 mutant mice, revealing that mutations in the frizzled 6 gene disrupted normal hair whorl patterns by affecting the signaling pathways that guide hair follicle orientation. Despite initial randomness, hair follicles reoriented over the first postnatal week to form locally ordered patterns, suggesting a secondary alignment mechanism independent of frizzled 6 and Celsr1 genes. The research highlighted the role of frizzled 6 in planar cell polarity and its importance in maintaining orderly hair arrangement, contributing to the understanding of genetic factors influencing hair pattern formation.
91 citations,
December 2006 in “Proceedings of the National Academy of Sciences” Hair patterns in mice are controlled by both a global system dependent on Fz6 and a local self-organizing system.
29 citations,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Loss of Fz6 disrupts hair follicle and associated structures' orientation.
33 citations,
June 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
24 citations,
January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
2 citations,
August 2023 in “Development” Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.
114 citations,
January 2016 in “Current topics in developmental biology/Current Topics in Developmental Biology” Frizzled receptors are essential for various body development processes and maintaining certain body functions.
