Frizzled Receptors in Development and Disease
January 2016
in “
Current topics in developmental biology/Current Topics in Developmental Biology
”
TLDR Frizzled receptors are essential for various body development processes and maintaining certain body functions.
The document "Frizzled Receptors in Development and Disease" reviewed the critical roles of Frizzled receptors in various biological processes and diseases. Key findings included the involvement of Frizzled3 in axonal development, Frizzled4 in retinal vascular development and blood-brain barrier maintenance, and Frizzled6 in hair follicle orientation. Mutations in these receptors were linked to conditions such as neural tube defects, familial exudative vitreoretinopathy, and nail dysplasia. The studies highlighted the complex interactions and essential functions of Frizzled receptors in development and disease, emphasizing the need for further research to fully understand their roles.
