TLDR Frizzled receptors are essential for various body development processes and maintaining certain body functions.
The document "Frizzled Receptors in Development and Disease" reviewed the critical roles of Frizzled receptors in various biological processes and diseases. Key findings included the involvement of Frizzled3 in axonal development, Frizzled4 in retinal vascular development and blood-brain barrier maintenance, and Frizzled6 in hair follicle orientation. Mutations in these receptors were linked to conditions such as neural tube defects, familial exudative vitreoretinopathy, and nail dysplasia. The studies highlighted the complex interactions and essential functions of Frizzled receptors in development and disease, emphasizing the need for further research to fully understand their roles.
28 citations,
October 2014 in “Development” Fz3 and Fz6 can partially replace each other in tissue polarity and axon guidance.
29 citations,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Loss of Fz6 disrupts hair follicle and associated structures' orientation.
55 citations,
November 2010 in “Development” Hair follicles in mutant mice self-organize into ordered patterns within a week.
91 citations,
December 2006 in “Proceedings of the National Academy of Sciences” Hair patterns in mice are controlled by both a global system dependent on Fz6 and a local self-organizing system.
29 citations,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Loss of Fz6 disrupts hair follicle and associated structures' orientation.
33 citations,
June 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
24 citations,
January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
55 citations,
November 2010 in “Development” Hair follicles in mutant mice self-organize into ordered patterns within a week.
8 citations,
May 2017 in “IUBMB life” Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.
