Pelage Announces Positive Results of Phase 2a Trials for PP405
    Update 6/17/2025

    At a glance
    In this treatment experience post, the primary subjects mentioned are
    💧 PP405 (topical) once daily 4 weeks
    the tone is mixed with 31% of users experienced over 20% hair density increase results.

    Other terms

    PP405 shows promise in treating severe hair loss, with 31% of users experiencing over 20% hair density increase in four weeks, faster than minoxidil and finasteride. Some users are skeptical about the results' significance and long-term efficacy.
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    6 / 386 results

      community Story time! The Great Unbalding (PP405)

      in Research/Science  229 upvotes 3 months ago
      PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

      community Minoxidil alone, 4 months consistent usage

      in Is this regrowth?  515 upvotes 4 months ago
      Minoxidil 5% foam was used twice daily for 4 months, resulting in visible hair regrowth. Users discussed adding finasteride for better long-term results, with concerns about its side effects and alternatives like breezula and clascoterone.

      community I'm sad I now lost enough hair I can only hide with a hat now

      in Chat  102 upvotes 5 months ago
      A 21-year-old is experiencing significant hair loss and considering treatments like dutasteride, minoxidil, and possibly a hair transplant. Others share their experiences with finasteride, scalp micropigmentation, and hair transplants, discussing the emotional impact and offering support.

      community The DEFINITIVE cure for hairloss

      in Satire  270 upvotes 7 months ago
      The conversation humorously suggests using immunosuppressants like ciclosporine and oral minoxidil for hair regrowth, with a satirical plan involving hair transplants from family members. It highlights the side effects and impracticality of such treatments, emphasizing the post's satirical nature.

      community Thoughts on the future of pp405?

      in Research/Science  43 upvotes 2 months ago
      PP405 is considered a promising hair loss treatment, potentially replacing minoxidil but not finasteride. Users are hopeful for future treatments like GT20029 and VDPHL01, while remaining cautious about effectiveness and side effects.

    Related Research

    6 / 20 results

      research PP405 in Alopecia: An Emerging Molecule Worth Investigating

      January 2026 in “Journal of Community Medicine and Health Solutions”
      PP405 is a promising new non-hormonal topical treatment for androgenetic alopecia (AA), which is the most common form of hair loss and often causes psychological distress. Current treatments like minoxidil and finasteride have limited efficacy and side effects, creating a need for better options. PP405 works by stimulating dormant hair follicle stem cells and modulating cellular metabolism. Early human studies show that PP405 is well tolerated with low systemic absorption. In a Phase 1 trial, a 0.05% gel increased markers of early hair regeneration, and a Phase 2a study showed a >20% increase in hair density in some men with advanced hair loss by week 8, without significant adverse events. While these results are promising, further large-scale, long-term trials are needed to confirm efficacy, optimal dosing, and safety. If successful, PP405 could become a novel treatment for AA.