Overactive Wnt5a Signaling Disrupts Hair Follicle Polarity During Mouse Skin Development

    October 2022 in “ Development ”
    Laura Simonson, Ethan Oldham, Hao Chang
    Studysummary This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.biologists.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    2. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Upper Hair Follicle Research Square (Research Square) · 2020
    3. Functional Redundancy of Frizzled 3 and Frizzled 6 in Planar Cell Polarity Control of Mouse Hair Follicles Development · 2018
    4. Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns Developmental Biology · 2017
    5. Partial Interchangeability of Fz3 and Fz6 in Tissue Polarity Signaling for Epithelial Orientation and Axon Growth and Guidance Development · 2014
    6. Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology Journal of Visualized Experiments · 2014
    7. Responses of Hair Follicle–Associated Structures to Loss of Planar Cell Polarity Signaling Proceedings of the National Academy of Sciences of the United States of America · 2013
    8. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    9. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    10. Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis Genes & development · 2010
    11. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009
    12. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005
    13. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999