Region-Specific Reversal of Epidermal Planar Polarity in the Rosette Fancy Mouse

    August 2023 in “ Development ”
    Maureen Cetera, Rishabh Sharan, Gabriela Hayward-Lara … Danelle Devenport
    Studysummary In this study, researchers explored how hair follicle orientation is affected in the rosette fancy mouse and found that a mutation in the PCP gene Fzd6 caused reversed hair orientations in the posterior region, leading to the formation of unique whorls.
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    Research cited in this study 9

    1. Celsr1 And Celsr2 Exhibit Distinct Adhesive Interactions And Contributions To Planar Cell Polarity Frontiers in cell and developmental biology · 2023
    2. Overactive Wnt5a Signaling Disrupts Hair Follicle Polarity During Mouse Skin Development Development · 2022
    3. Functional Redundancy of Frizzled 3 and Frizzled 6 in Planar Cell Polarity Control of Mouse Hair Follicles Development · 2018
    4. Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns Developmental Biology · 2017
    5. Partial Interchangeability of Fz3 and Fz6 in Tissue Polarity Signaling for Epithelial Orientation and Axon Growth and Guidance Development · 2014
    6. Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology Journal of Visualized Experiments · 2014
    7. When Whorls Collide: The Development of Hair Patterns in Frizzled 6 Mutant Mice Development · 2010
    8. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009
    9. Order From Disorder: Self-Organization In Mammalian Hair Patterning Proceedings of the National Academy of Sciences · 2006