Planar Cell Polarity Effector Gene Intu Regulates Cell Fate-Specific Differentiation of Keratinocytes Through the Primary Cilia

    August 2012 in “ Cell death and differentiation ”
    Dongfang Dai, L Li, Aaron J. Huebner … J Chen
    Studysummary This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.
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    Research cited in this study 11

    1. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    2. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009
    3. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    4. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    5. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    6. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    7. Mice Expressing a Mutant KRT75 (K6hf) Allele Develop Hair and Nail Defects Resembling Pachyonychia Congenita Journal of Investigative Dermatology · 2007
    8. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    9. Rac1 Is Crucial for Hair Follicle Integrity but Not Essential for Epidermis Maintenance Molecular and Cellular Biology · 2006
    10. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    11. Molecular Biology of Hair Morphogenesis: Development and Cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003