Planar Cell Polarity Effector Gene Intu Regulates Cell Fate-Specific Differentiation of Keratinocytes Through the Primary Cilia
August 2012
in “
Cell death and differentiation
”
planar cell polarity PCP Intu gene hair follicle formation keratinocytes primary cilia hair follicle morphogenesis hedgehog signaling pathway epidermal stratification differentiation programs barrier function Intu hair follicles skin cells cilia hedgehog pathway skin layers skin differentiation skin barrier
Studysummary This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.
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This study investigated the role of the planar cell polarity (PCP) effector gene Intu in hair follicle formation in mice. Disrupting Intu in embryonic epidermis led to arrested hair follicle morphogenesis due to the failure of follicular keratinocytes to differentiate. This disruption also caused a near-complete loss of primary cilia in epidermal and follicular keratinocytes and suppressed the hedgehog signaling pathway, although epidermal stratification, differentiation programs, and barrier function remained unaffected. The findings demonstrated that tissue-specific PCP effector genes regulate keratinocyte differentiation through primary cilia in a cell fate- and context-dependent manner, crucial for interpreting polarity signals from core PCP components.
