Celsr1 And Celsr2 Exhibit Distinct Adhesive Interactions And Contributions To Planar Cell Polarity

January 2023 in “ Frontiers in cell and developmental biology ”

Lena P. Basta, Parijat Sil, Rebecca A. Jones, Katherine A. Little, Gabriela Hayward-Lara, Danelle Devenport

Celsr1 Celsr2 planar cell polarity PCP hair follicles CRISPR/Cas9 epidermal PCP Vangl2 Fz6 homophilic adhesion CRISPR

Studysummary This study found that Celsr1, not Celsr2, is the primary protein involved in establishing planar cell polarity and hair follicle polarization in the epidermis of mice.

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This study found that disrupting the inturned gene in developing mouse epidermis halted hair follicle formation due to impaired keratinocyte differentiation, highlighting primary cilia's role in tissue-specific planar cell polarity signaling.

research Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse

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