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GlossaryPlanar Cell Polarity

coordinated orientation of cells within tissue plane

Planar Cell Polarity (PCP) refers to the coordinated orientation of cells along a tissue plane, rather than just up and down. This is crucial for various biological processes, such as the uniform direction of hair growth on the skin or the proper alignment of cells in the inner ear for hearing.

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research Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns

33 citations, June 2017 in “Developmental Biology”

Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.

research Responses of Hair Follicle–Associated Structures to Loss of Planar Cell Polarity Signaling

29 citations, February 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Loss of Fz6 disrupts hair follicle and associated structures' orientation.

research Functional Redundancy of Frizzled 3 and Frizzled 6 in Planar Cell Polarity Control of Mouse Hair Follicles

24 citations, January 2018 in “Development”

Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.

research Planar Cell Polarity Effector Gene Intu Regulates Cell Fate-Specific Differentiation of Keratinocytes Through the Primary Cilia

19 citations, August 2012 in “Cell death and differentiation”

Intu gene is crucial for hair follicle formation by helping keratinocytes differentiate through primary cilia.

research Celsr1 And Celsr2 Exhibit Distinct Adhesive Interactions And Contributions To Planar Cell Polarity

7 citations, January 2023 in “Frontiers in cell and developmental biology”

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

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