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    Glossary Planar Cell Polarity

    coordinated orientation of cells within tissue plane

    Planar Cell Polarity (PCP) refers to the coordinated orientation of cells along a tissue plane, rather than just up and down. This is crucial for various biological processes, such as the uniform direction of hair growth on the skin or the proper alignment of cells in the inner ear for hearing.

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    1. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009 · 92 citations
    2. Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns Developmental Biology · 2017 · 33 citations
    3. Responses of hair follicle–associated structures to loss of planar cell polarity signaling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 29 citations
    4. Functional redundancy of <i>Frizzled 3</i> and <i>Frizzled 6</i> in planar cell polarity control of mouse hair follicles Development · 2018 · 24 citations
    5. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    6. Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity Frontiers in cell and developmental biology · 2023 · 7 citations
    7. 236 Wnt/planar cell polarity impairment and the genetics of yellow nail syndrome Journal of Investigative Dermatology · 2024
    8. Region-specific reversal of epidermal planar polarity in the <i>rosette</i> fancy mouse Development · 2023 · 2 citations
    9. Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development Development · 2022 · 7 citations
    10. 851 The role of astrotactin2 in regulating mammalian skin polarity 2017
    11. Co-opting Developmental Signaling Pathways to Promote Wound Healing Recent clinical techniques, results, and research in wounds · 2018 · 1 citations
    12. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    13. Cell Polarization Defects in Early Heart Development Circulation Research · 2007 · 9 citations
    14. Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems The International Journal of Developmental Biology · 2023 · 21 citations
    15. When whorls collide: the development of hair patterns in frizzled 6 mutant mice Development · 2010 · 55 citations
    16. Barley disease susceptibility factor RACB acts in epidermal cell polarity and positioning of the nucleus Journal of experimental botany · 2016 · 41 citations
    17. Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling EMBO journal · 2021 · 5 citations
    18. GWASs Identify Genetic Loci Associated with Human Scalp Hair Whorl Direction Journal of Investigative Dermatology · 2023 · 4 citations
    19. Epidermal Polarity Genes in Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 32 citations
    20. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    21. Molecular mechanisms of asymmetric divisions in mammary stem cells EMBO Reports · 2016 · 79 citations
    22. Gene Expression During Drosophila Wing Morphogenesis and Differentiation Genetics · 2005 · 57 citations
    23. Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity Nature Communications · 2019 · 38 citations
    24. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    25. Reporting Live from the Epidermal Stem Cell Compartment! Cell Stem Cell · 2012 · 2 citations
    26. Developmental Mechanisms Controlling Cell Fate, Evolution of Elsevier eBooks · 2016
    27. Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy PLoS ONE · 2016 · 31 citations
    28. The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size Nature Communications · 2025 · 1 citations
    29. Hardwiring Stem Cell Communication through Tissue Structure Cell · 2016 · 82 citations
    30. From basic biology to engineered therapies: the keratinocyte stem cell playbook Frontiers in Medical Technology · 2026