Wnt Signaling Activation: Targets and Therapeutic Opportunities for Stem Cell Therapy and Regenerative Medicine

    January 2021 in “ RSC chemical biology ”
    Clémence Bonnet, Anvi Brahmbhatt, Sophie X. Deng, Jie Zheng
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    TLDR Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.
    The document reviewed the potential of Wnt signaling activators in stem cell therapy and regenerative medicine, emphasizing their role in embryonic development, stem cell proliferation, self-renewal, and tissue regeneration. It discussed various strategies for developing Wnt activators, such as Wnt mimics, antibodies, GSK-3ß inhibitors, and natural product derivatives, which could treat a range of disorders and prevent aging. However, it also highlighted the challenges in creating selective activators without adverse effects like cancer. The review mentioned that no Wnt pathway therapies are FDA-approved, with few in clinical trials, but small-molecule Wnt regulators have been useful in research. It also noted the promise of GSK-3ß inhibitors in animal models for Alzheimer's and melanoma, the need for further research to understand the effects of Wnt activators on healthy tissues, and the challenges in developing safe and effective Wnt-based therapies. The document concluded that while Wnt activation is promising for regenerative medicine, there is a need for highly selective and cell-type specific targets to minimize risks, such as cancer, associated with Wnt pathway dysregulation.
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