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GlossaryGlycogen Synthase Kinase-3 Inhibitor (GSK-3 Inhibitor)

compound that blocks the enzyme GSK-3, affecting cell processes

A Glycogen Synthase Kinase-3 Inhibitor (GSK-3 Inhibitor) is a type of compound that blocks the activity of the enzyme glycogen synthase kinase-3 (GSK-3). This enzyme is involved in various cellular processes, including the regulation of glycogen metabolism, cell division, and signaling pathways. Inhibiting GSK-3 has potential therapeutic applications for conditions like Alzheimer's disease, diabetes, and certain types of cancer, as well as promoting hair growth in cases of alopecia.

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research Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells

20 citations , August 2015 in “International Journal of Molecular Medicine”

Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.

Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

research Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

10 citations , May 2019 in “BMC Complementary and Alternative Medicine”

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

research Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

7 citations , January 2020 in “International Journal of Molecular Sciences”

Low-frequency electromagnetic fields can boost molecules related to hair growth in human skin cells.

Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

research Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

4 citations , June 2021 in “Journal of Microbiology and Biotechnology”

Ginsenoside Rg4 from ginseng may help hair growth by activating certain cell signals.

research GSK-3 Inhibitors: Recent Developments and Therapeutic Potential

3 citations , September 2008 in “Current signal transduction therapy”

Drugs that block GSK-3 show promise for treating various diseases.

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community Why is dutasteride approved for hair loss in Japan and South Korea but not for USA?

in Research/Science 34 upvotes 3 years ago

The reasoning for GSK's approval of dutasteride for hair loss in Japan and South Korea but not the US, with alternatives such as finasteride, minoxidil and RU58841 mentioned.

community About those dutasteride studies 😒

in Research/Science 22 upvotes 4 months ago

Dutasteride studies for hair loss are often sponsored by GlaxoSmithKline, raising concerns about potential bias. Despite this, some users report positive results with dutasteride and oral minoxidil, while others remain skeptical of industry-funded research.

community Trialing the probiotics BB536, PTA 6475 so you don’t have to

in Research/Science 72 upvotes 2 months ago

Probiotics like L. reuteri ATCC PTA 6475 and B. longum BB536 may improve hair growth and density by reducing inflammation and reversing DHT damage. The user is trialing these probiotics personally, ordering them from the U.S. to Canada, and plans to continue if no adverse effects occur.

community Topical Valproic acid/sodium valproate — has anyone tried this?

in Question 2 upvotes 5 years ago

The conversation is about using valproic acid, an anti-seizure medication, as a topical treatment to promote hair growth. The original poster is seeking personal experiences from those who have tried this method.

community 24M - 14 months of treatment (diffuse thinning)

in Progress Pictures 708 upvotes 2 weeks ago

A 24-year-old male experienced significant hair regrowth after 14 months of treatment with 0.5mg dutasteride and 5mg minoxidil, with no side effects reported. He plans to consider a hair transplant for his hairline, as the treatment did not improve that area.

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