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Did you mean GSK-3 Inhibitor?

GlossaryGlycogen Synthase Kinase-3 Inhibitor (GSK-3 Inhibitor)

compound that blocks the enzyme GSK-3, affecting cell processes

A Glycogen Synthase Kinase-3 Inhibitor (GSK-3 Inhibitor) is a type of compound that blocks the activity of the enzyme glycogen synthase kinase-3 (GSK-3). This enzyme is involved in various cellular processes, including the regulation of glycogen metabolism, cell division, and signaling pathways. Inhibiting GSK-3 has potential therapeutic applications for conditions like Alzheimer's disease, diabetes, and certain types of cancer, as well as promoting hair growth in cases of alopecia.

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research Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells

20 citations, August 2015 in “International Journal of Molecular Medicine”

Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.

Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

research Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

10 citations, May 2019 in “BMC Complementary and Alternative Medicine”

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

research Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

7 citations, January 2020 in “International Journal of Molecular Sciences”

Low-frequency electromagnetic fields can boost molecules related to hair growth in human skin cells.

Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

research Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

4 citations, June 2021 in “Journal of Microbiology and Biotechnology”

Ginsenoside Rg4 from ginseng may help hair growth by activating certain cell signals.

research GSK-3 Inhibitors: Recent Developments and Therapeutic Potential

3 citations, September 2008 in “Current signal transduction therapy”

Drugs that block GSK-3 show promise for treating various diseases.

research Low Molecular Weight Collagen Peptide Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling Pathway

September 2023 in “Journal of microbiology and biotechnology”

A type of collagen helps hair grow by boosting cell growth and activating a specific hair growth pathway.

research Ginsenoside Rb1 Promotes the Growth of Mink Hair Follicle via PI3K/AKT/GSK-3β Signaling Pathway

28 citations, May 2019 in “Life Sciences”

Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.

research Corrigendum to: Low Molecular Weight Collagen Peptide Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling Pathway

April 2024 in “Journal of microbiology and biotechnology”

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations, May 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

research The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

1 citations, November 2020 in “Journal of The American Academy of Dermatology”

GSK-36 downregulation with UTMD improves plaque stability in atherosclerosis treatment.

research CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2

February 2023 in “Cells”

Targeting CXXC5 and GSK-3β may help treat male pattern baldness.

research Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model

48 citations, June 2013 in “Journal of Dermatological Science”

Valproic acid may help hair grow and could be a safe treatment for hair loss.

research Effect of Sinapic Acid on Hair Growth Promotion in Human Hair Follicle Dermal Papilla Cells via Akt Activation

25 citations, March 2017 in “Archives of Dermatological Research”

Sinapic acid may help hair growth by activating a specific cell pathway.

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

19 citations, May 2020 in “Cells”

Substance from human umbilical cord blood cells promotes hair growth.

research The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells

14 citations, March 2019 in “Journal of Cosmetic Dermatology”

Activated platelet-rich plasma helps hair growth by boosting growth factors and cell growth pathways in hair cells.

research Wnt Signaling Activation: Targets and Therapeutic Opportunities for Stem Cell Therapy and Regenerative Medicine

13 citations, January 2021 in “RSC chemical biology”

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

research Sustained Release of Inhibitor from Bionic Scaffolds for Wound Healing and Functional Regeneration

8 citations, January 2020 in “Biomaterials Science”

Researchers developed a scaffold that releases a healing drug over time, improving wound healing and skin regeneration.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

6 citations, May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In Vitro and In Vivo Assessments

1 citations, January 2015 in “Journal of clinical and investigative dermatology”

IGF-1 from human placenta helps hair grow.

research The Metabolites of Bifidobacterium Longum BB536 Alleviate DHT-Damaged Human Dermal Papilla Cells by Activating WNT/β-Catenin Signaling

August 2024 in “Food Bioscience”

Bifidobacterium longum BB536 metabolites may help treat hair loss by repairing and promoting hair cell growth.

research Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells

July 2024 in “International Journal of Molecular Sciences”

The inhibitor DPP can promote hair growth.

research AP Collagen Peptides (APCPs) Promote Hair Growth by Activating the GSK-3β/β-Catenin Pathway and Improve Hair Condition

July 2024 in “Experimental Dermatology”

AP collagen peptides help hair grow and improve hair health.

research Exploring the Role of UC-MSC-Derived Exosomes in Boosting HHDPCs Proliferation for Hair Growth via AKT Activation

January 2024

UC-MSC-derived exosomes may help treat hair loss by promoting hair cell growth through AKT activation.

Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

research Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

July 2023 in “Current Issues in Molecular Biology”

Escin may help treat hair loss by boosting a specific cell growth pathway.

research Discovering Hair Loss Treatments That Increase The Wnt/Beta-Catenin Signaling Pathway By High-Throughput Screening

April 2023 in “Journal of Investigative Dermatology”

Aminoacridine and Abemaciclib, especially combined with Minoxidil, show promise for treating hair loss.

research Cold Atmospheric Microwave Plasma Stimulates Dermal Papilla Cell Proliferation by Inducing Beta-Catenin Signaling

February 2023 in “Scientific Reports”

Cold Atmospheric Microwave Plasma (CAMP) helps hair cells grow and could potentially treat hair loss.

research Effect of Fermented Mackerel Oil on Hair Growth

September 2017 in “Journal of Investigative Dermatology”

Fermented mackerel oil was found to promote hair growth by activating certain cell signals and increasing cell growth.

research Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture

23 citations, January 2020 in “Frontiers in Pharmacology”

Dihydrotestosterone affects hair growth by changing the Wnt/β-catenin pathway, with low levels helping and high levels hindering growth.

research Photobiomodulation Promotes Hair Regeneration in Injured Skin by Enhancing Migration and Exosome Secretion of Dermal Papilla Cells

13 citations, December 2021 in “Wound repair and regeneration”

Photobiomodulation helps hair regrow in injured skin by aiding cell movement and secretion.

research The Promoting Effect of Rumex Japonicas Houttuyn Ethanol Extract on Hair Growth

December 2020 in “Daehanhanuihakoeji”

Rumex japonicas Houttuyn ethanol extract helps increase hair growth and protect against hair damage.