Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives

    March 2020 in “ Cells
    Artem Blagodatski, Antonina Klimenko, Jia Li, Vladimir L. Katanaev
    TLDR Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
    The document reviewed the history, current state, and future perspectives of small molecule Wnt pathway modulators derived from natural sources, emphasizing their therapeutic potential in treating conditions like cancer, osteoporosis, and hair loss. It highlighted various natural compounds, such as extracts from Aconiti Ciliare Tuber and Undariopsis peterseniana, which promoted hair growth by activating the Wnt/β-catenin pathway, and quercetin, which inhibited cancer cell proliferation. The review underscored the significance of these natural products in drug discovery and the need for further research to optimize their efficacy.
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