Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives

March 2020 in “ Cells ”

Artem Blagodatski, Antonina Klimenko, Jia Li, Vladimir L. Katanaev

Wnt signaling pathway small molecule modulators regenerative therapies skin bioactive molecules

Studysummary This review provides an overview of natural product-derived small molecule modulators of the Wnt signaling pathway, exploring their potential as therapeutic agents for tissue regeneration and cancer treatment.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviewed the history, current state, and future perspectives of small molecule Wnt pathway modulators derived from natural sources, emphasizing their therapeutic potential in treating conditions like cancer, osteoporosis, and hair loss. It highlighted various natural compounds, such as extracts from Aconiti Ciliare Tuber and Undariopsis peterseniana, which promoted hair growth by activating the Wnt/β-catenin pathway, and quercetin, which inhibited cancer cell proliferation. The review underscored the significance of these natural products in drug discovery and the need for further research to optimize their efficacy.

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5 / 5 results

research Wnt Is Back in Drugmakers' Sights, but Is It Druggable?

10 citations , November 2018 in “Nature Biotechnology”

Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.

research Undariopsis Peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways

27 citations , May 2017 in “Marine Drugs”

This study found that Undariopsis peterseniana extract may promote hair growth by activating specific cellular pathways, suggesting potential for treating alopecia.

research Therapeutic Advances in Trichology

20 citations , January 2017 in “Actas Dermo-Sifiliográficas”

This review discusses recent therapeutic advances in treating various types of hair loss, including androgenetic alopecia, alopecia areata, frontal fibrosing alopecia, and hair transplant technologies, but reports no new clinical results.

research Targeting the Wnt Pathways for Therapies

112 citations , January 2014 in “Molecular and cellular therapies”

This review summarizes the current understanding of Wnt signaling in relation to its roles in tissue regeneration and cancer progression and discusses recent medical advancements targeting this pathway for therapeutic purposes.

research Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling

45 citations , September 2012 in “Life Sciences”

This study observed that Aconiti Ciliare Tuber extract may promote hair growth in mice by activating the Wnt/β-catenin signaling pathway.