In Vitro Hair Growth-Promoting Effects of Araliadiol via the p38/PPAR-γ Signaling Pathway in Human Hair Follicle Stem Cells and Dermal Papilla Cells

    December 2024 in “ Frontiers in Pharmacology
    Seokmuk Park, Han Woong Park, Dae Bang Seo, Dae Sung Yoo, Seunghee Bae
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    TLDR Araliadiol may promote hair growth like minoxidil without being toxic.
    This study examines the potential of araliadiol, a compound from Centella asiatica, to promote hair growth by activating the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells. Araliadiol was found to enhance the expression of hair growth-related proteins such as VEGF, ANGPTL4, and PPAR-γ, and increase cell proliferation without cytotoxicity at concentrations up to 5 μg/mL. The compound's effects were comparable to minoxidil, a known hair growth treatment, suggesting its potential as a botanical alternative for alopecia treatment. The study highlights the need for further in vivo research to confirm araliadiol's efficacy and safety.
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