Lymphatic Vasculature and Hair Follicle Regeneration

    Anna Cazzola, Mirna Perez-Moreno
    TLDR Lymphatic vessels help hair follicles regenerate by interacting with stem cells.
    The document explores the active role of lymphatic vessels (LV) in hair follicle (HF) regeneration, beyond their traditional function of fluid drainage. It highlights the interaction between LVs, hair follicle stem cells (HFSC), and the dermal papilla (DP), which influences HF growth and regeneration. HFSCs recruit LVs to their niche, with LVs surrounding the HF bulge and connecting neighboring HFs. The regulation of LVs by HFSCs varies with the HF stage, affecting LV flow and tissue drainage. Gene expression changes in HFSCs and LVs are linked to LV reorganization, driven by HFSC-secreted proteins. This study suggests a complex crosstalk between LVs and HFSCs, with potential implications for regenerative therapies and disease treatment, although further research is needed to fully understand this interaction.
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