PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology

    December 2019 in “ Experimental Dermatology
    Yuval Ramot, Marta Bertolini, M. Boboljova, Yoshikazu Uchida, Ralf Paus
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    TLDR PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.
    The 2019 document discussed the role of PPAR-γ signalling in human hair follicle physiology and pathology. PPAR-γ, a nuclear hormone receptor, is expressed in human skin and its appendages, and is involved in lipid synthesis, keratinocyte differentiation, barrier homeostasis, and sebocyte differentiation. It was found to impact hair follicle growth, cycling, protein production, and epithelial stem cell homeostasis. Abnormalities in PPAR-γ signalling were found in patients with lichen planopilaris, a type of scarring alopecia. The study also found that PPAR-γ agonists could inhibit or even reverse epithelial-mesenchymal transition, a process leading to scarring alopecia. PPAR-γ signalling was also suggested to play a role in androgenetic alopecia and hirsutism. The document concluded that further clinical trials were needed to fully understand the correct dosing and safety profile of PPAR-γ modulators.
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