Peroxisome Proliferator-Activated Receptor-Gamma Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

February 2018 in “ Journal of Investigative Dermatology ”

Yuval Ramot, Majid Alam, Attila Oláh, Tamás Bı́ró, L. Ponce, Jeremy Chéret, Marta Bertolini, Ralf Paus

PPAR-γ peroxisome proliferator-activated receptor gamma mitochondrial energy metabolism human hair follicles N-acetyl-GED-0507-34-Levo outer root sheath keratinocytes ATP release catagen hair matrix keratinocyte proliferation

TLDR PPAR-γ signaling improves mitochondrial function in hair follicles, potentially affecting hair growth and aging.

The study investigated the role of PPAR-γ-mediated signaling in regulating mitochondrial energy metabolism in human hair follicles, using the selective PPAR-γ modulator N-acetyl-GED-0507-34-Levo. It found that N-acetyl-GED significantly up-regulated genes and proteins associated with mitochondrial function, particularly in outer root sheath keratinocytes, suggesting these cells are primary targets of PPAR-γ activation. Additionally, N-acetyl-GED induced catagen and decreased hair matrix keratinocyte proliferation, supporting the idea that hair follicles primarily engage in aerobic glycolysis. These findings suggested that PPAR-γ signaling could influence hair follicle energy metabolism, potentially offering insights into anti-aging treatments for hair follicles.

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Research cited in this study

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research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives

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research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation

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research Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles

95 citations , August 2013 in “Journal of Investigative Dermatology”

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research Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions

61 citations , July 2011 in “PLOS ONE”

Spermidine may help reduce hair loss and deserves further testing as a treatment.

research Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue

71 citations , June 1993 in “Journal of Investigative Dermatology”

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