Peroxisome Proliferator-Activated Receptor-Gamma Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

    February 2018 in “ Journal of Investigative Dermatology ”
    Yuval Ramot, Majid Alam, Attila Oláh … Ralf Paus
    Studysummary This study found that the PPAR-γ modulator N-acetyl-GED may enhance mitochondrial function in human hair follicles, particularly in outer root sheath keratinocytes.
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    Research cited in this study 7

    1. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    2. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    3. The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology Experimental Dermatology · 2015
    4. Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    5. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013
    6. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    7. Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue Journal of Investigative Dermatology · 1993