Peroxisome Proliferator-Activated Receptor-Gamma Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium

February 2018 in “ Journal of Investigative Dermatology ”

Yuval Ramot, Majid Alam, Attila Oláh, Tamás Bı́ró, L. Ponce, Jeremy Chéret, Marta Bertolini, Ralf Paus

PPAR-γ peroxisome proliferator-activated receptor gamma mitochondrial energy metabolism human hair follicles N-acetyl-GED-0507-34-Levo outer root sheath keratinocytes ATP release catagen hair matrix keratinocyte proliferation

TLDR PPAR-γ signaling improves mitochondrial function in hair follicles, potentially affecting hair growth and aging.

The study explored the impact of PPAR-γ-mediated signaling on mitochondrial energy metabolism in human hair follicles using organ-cultured human scalp HFs. It was found that the selective PPAR-γ modulator, N-acetyl-GED-0507-34-Levo, significantly enhanced mitochondrial function by up-regulating genes and proteins in outer root sheath keratinocytes, leading to increased ATP release. This suggested improved mitochondrial activity, which could influence hair growth phases by promoting catagen and inhibiting hair matrix keratinocyte proliferation. The study suggested further research to understand the clinical implications, including potential anti-aging effects on hair follicles.

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