Mitochondrial Dysfunction in Metabolic Syndrome and Inflammatory Skin Disease

The article discusses the role of mitochondrial dysfunction in the pathogenesis of metabolic syndrome and inflammatory skin diseases, such as psoriasis, atopic dermatitis, acne, and androgenetic alopecia. It highlights how oxidative stress, inflammation, and insulin resistance link these conditions, emphasizing the need for targeted therapies. The document suggests nonpharmacologic interventions like exercise and caloric restriction, alongside pharmacologic treatments such as metformin and antioxidant therapy, to address mitochondrial dysfunction. It also recommends routine screening for metabolic dysfunction in patients with inflammatory skin diseases to manage cardiovascular and insulin resistance risks. The article calls for further research to explore genetic factors and develop effective treatments, while acknowledging barriers like global health disparities and mental health challenges that affect management.