Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis

    Xiaoxia Ding, Zhigang Bai, Wenwen Wang, Yu Gu, Zhiming Li, Yibin Fan
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    TLDR Higher fasting insulin levels increase the risk of androgenetic alopecia.
    This study used Mendelian randomization to investigate the causal relationship between fasting insulin (FI) levels and androgenetic alopecia (AGA), analyzing data from 212,453 AGA samples and 151,013 individuals for FI. It found a significant causal link between elevated FI levels and increased AGA risk, but not the reverse. The study identified 92 FI-associated genes, with EIF2B4 and NRBP1 as potential core genes, suggesting that glycosylation and amino acid metabolism may be crucial pathways. These findings highlight the influence of metabolic dysregulation on AGA and suggest potential targets for prevention and treatment, though the study's focus on European populations limits its generalizability.
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