Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis

    February 2025 in “ Clinical Cosmetic and Investigational Dermatology ”
    Xiaoxia Ding, Zhigang Bai, Wenwen Wang … Yibin Fan
    Studysummary This study used Mendelian randomization analysis to find a significant causal relationship between high fasting insulin levels and androgenetic alopecia, while identifying potential core genes and metabolic pathways that could mediate this link.
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    Research cited in this study 20

    1. Causal Effects of Genetically Determined Metabolites on Androgenetic Alopecia: A Two-Sample Mendelian Randomization Analysis Skin research and technology · 2024
    2. A Hospital-Based Study to Assess the Prevalence of Androgenetic Alopecia in Young Male Patients Admitted to a Cardiac Care Unit 2023
    3. Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition from Telogen to Anagen Phase Frontiers in Cell and Developmental Biology · 2022
    4. Natural Products for Male Androgenetic Alopecia Dermatologic Therapy · 2022
    5. Systematic Review and Meta-Analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia Acta dermato-venereologica · 2021
    6. Association of Early-Onset Androgenetic Alopecia and Metabolic Syndrome JCPSP. Journal of the College of Physicians & Surgeons Pakistan · 2021
    7. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    8. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    9. Male-Pattern Baldness and Incident Coronary Heart Disease and Risk Factors in the Heinz Nixdorf Recall Study PLoS ONE · 2019
    10. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    11. Viable Terminal Scalp Hair Follicles Are Necessary and Sufficient for Clinical Efficacy of Finasteride in Male Pattern Hair Loss Skin Research and Technology · 2019
    12. Microbiome in the Hair Follicle of Androgenetic Alopecia Patients PLOS ONE · 2019
    13. The Association of Metabolic Syndrome and Insulin Resistance in Early-Onset Androgenetic Alopecia in Males: A Case-Control Study Indian Journal of Dermatology · 2019
    14. Clinical Profile of Androgenic Alopecia and Its Association with Cardiovascular Risk Factors Indian Journal of Dermatology · 2019
    15. A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth Experimental Dermatology · 2018
    16. Association of Androgenetic Alopecia with Metabolic Syndrome: A Case-Control Study on 100 Patients in a Tertiary Care Hospital in South India Indian Journal of Endocrinology and Metabolism · 2018
    17. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    18. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    19. Therapeutic Hotline: Genetic Variations in the Androgen Receptor Gene and Finasteride Response in Women with Androgenetic Alopecia Mediated by Epigenetics Dermatologic Therapy · 2011
    20. Androgenic Alopecia and Insulin Resistance: Are They Really Related? Clinical and Experimental Dermatology · 2009