Natural Products for Male Androgenetic Alopecia

January 2022 in “ Dermatologic Therapy ”

Anik Gupta, Mesbah Uddin Talukder, Mary A Bamimore

androgenetic alopecia minoxidil finasteride saw palmetto caffeine melatonin marine extracts rosemary oil procyanidin pumpkin seed oil cannabidiol oil AGA Rogaine Propecia CBD oil

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Saw Palmetto →

a natural and far less effective alternative to Finasteride

Studysummary Natural products like saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil could potentially treat male hair loss.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

20 / 20 results

research Lasers, Lights, and Compounds for Hair Loss in Aesthetics

3 citations , August 2021 in “Clinics in Dermatology”

This review discusses various treatments for hair loss, such as topical agents, oral minoxidil, and laser therapies, but reports no new clinical results; debates on issues like post-finasteride syndrome are also covered.

research Cannabinoids for Skin Diseases and Hair Regrowth

20 citations , August 2021 in “Journal of Cosmetic Dermatology”

This review examines the potential use and challenges of topical cannabinoids for skin diseases and hair growth, highlighting limited clinical data on their efficacy and safety.

research Finasteride for Hair Loss: A Review

4 citations , July 2021 in “Journal of Dermatological Treatment”

This meta-analysis reported that finasteride 1 mg/day significantly increased hair count in male androgenetic alopecia compared to placebo, but highlighted persistent sexual side effects and associated depression risk.

research Minoxidil: A Comprehensive Review

16 citations , June 2021 in “Journal of Dermatological Treatment”

This study reported that while topical minoxidil exhibits hair regrowth in androgenetic alopecia, oral minoxidil 5 mg/day was more effective than topical forms after six months, with low doses also potentially effective for women and other hair loss types.

research Serum Levels of Androgen-Associated Hormones Are Correlated with Curative Effect in Androgenic Alopecia in Young Men

9 citations , October 2018 in “Medical Science Monitor”

In this study, oral finasteride therapy was associated with decreased DHT levels and improved hair loss severity in young male AGA patients, while hormonal changes influenced the curative effect.

research Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

40 citations , August 2018 in “Skin appendage disorders”

This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.

An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia

research An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia

21 citations , January 2017 in “Skin Pharmacology and Physiology”

In this noninferiority study, researchers found that a 0.2% caffeine-based topical liquid was not less effective than 5% minoxidil solution in improving hair growth in men with androgenetic alopecia over six months.

A 6-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of a Marine Complex Supplement to Promote Hair Growth in Men with Thinning Hair

research A 6-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of a Marine Complex Supplement to Promote Hair Growth in Men with Thinning Hair

25 citations , August 2016 in “Journal of Cosmetic Dermatology”

This study found that a marine complex supplement significantly reduced hair shedding and increased hair growth in men with thinning hair over 180 days.

research Treatment of Male Androgenetic Alopecia with Topical Products Containing Serenoa Repens Extract

18 citations , May 2015 in “Australasian Journal of Dermatology”

This study found that topical application of Serenoa repens extract increased hair count in men with androgenetic alopecia, suggesting it could be an alternative for those unable to use standard medications.

Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

60 citations , May 2014 in “British Journal of Dermatology”

This study found that caffeine enhanced hair growth and keratinocyte proliferation in human hair follicles, with female follicles showing greater sensitivity than male ones.

research Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

36 citations , January 2014 in “Evidence-based Complementary and Alternative Medicine”

This study found that men with androgenetic alopecia treated with pumpkin seed oil for 24 weeks experienced a notable 40% increase in hair count compared to a 10% increase with a placebo.

research Comparative Effectiveness of Finasteride vs Serenoa Repens in Male Androgenetic Alopecia: A Two-Year Study

51 citations , October 2012 in “International Journal of Immunopathology and Pharmacology”

In this study, 68% of patients treated with finasteride showed improved hair growth in male androgenetic alopecia, compared to 38% with Serenoa repens, indicating finasteride's superior efficacy.

research Topical Melatonin for Treatment of Androgenetic Alopecia

39 citations , January 2012 in “International Journal of Trichology”

This study found that topical melatonin solution was associated with positive effects on hair density and reduction in hair loss for androgenetic alopecia, with good tolerability reported in several clinical trials.

research A Mouse Model of Androgenetic Alopecia

42 citations , March 2010 in “Endocrinology”

This study reports the development of the first rodent model for androgenetic alopecia, demonstrating that overexpression of androgen receptors in mice delays hair regeneration and can be used to test new treatments.

research Melatonin and the Hair Follicle

109 citations , October 2007 in “Journal of pineal research”

This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.

research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

This study found that caffeine can stimulate hair growth in vitro and counteract testosterone-induced growth suppression in hair follicles from male AGA patients.

research Procyanidin Oligomers Counteract TGF-β1- and TGF-β2-Induced Apoptosis in Hair Epithelial Cells: An Insight into Their Mechanisms

14 citations , January 2006 in “Skin pharmacology and physiology”

This study found that procyanidin oligomers from apples and barley may stimulate hair growth by promoting hair epithelial cell proliferation and protecting them from apoptosis via MEK activation in a murine model.

Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

research Investigation of the Topical Application of Procyanidin Oligomers from Apples to Identify Their Potential Use as a Hair-Growing Agent

28 citations , December 2005 in “Journal of cosmetic dermatology”

This study found that 0.7% apple procyanidin oligomers applied externally for six months significantly increased hair growth in men with male pattern baldness compared to placebo, with no observed adverse effects.

A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

68 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.

research Investigation of Topical Application of Procyanidin B-2 from Apple to Identify Its Potential Use as a Hair Growing Agent

32 citations , December 2000 in “Phytomedicine”

In this study, 1% procyanidin B-2 tonic significantly increased the number of total and terminal hairs on the scalp of male participants compared to a placebo after 6 months of use.