Lasers, Lights, and Compounds for Hair Loss in Aesthetics

August 2021 in “ Clinics in Dermatology ”

Christina Ring, Robert Finney, Marc R. Avram

minoxidil finasteride latanoprost retinoic acid antioxidants biotin nutraceuticals platelet-rich plasma topical therapy oral therapy compounding pharmacies Rogaine Propecia PRP

TLDR Minoxidil is the main over-the-counter treatment for hair loss, with other options like finasteride, latanoprost, retinoic acid, antioxidants, biotin, nutraceuticals, and platelet-rich plasma therapy also showing promise.

Topical therapy, specifically the use of minoxidil, remains the main treatment for hair loss. Minoxidil is effective for both men and women and is available over the counter in concentrations of 2% and 5%. Other topical agents such as finasteride, latanoprost, retinoic acid, and antioxidants have also shown some evidence of effectiveness. Compounding pharmacies are needed to obtain specialized solutions. Oral therapy, such as finasteride and minoxidil, is sometimes preferred for convenience, but they come with potential side effects. Biotin supplementation and nutraceuticals are also popular options, although there is limited evidence supporting their efficacy. Platelet-rich plasma (PRP) therapy is another treatment option that shows promise. Overall, there are a variety of treatment options available for hair loss, and many of them are safe and promising.

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55 / 55 results

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research Oral Minoxidil: A Possible New Therapy for Androgenetic Alopecia

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research Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial

53 citations , August 2019 in “Journal of The American Academy of Dermatology”

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research Post-Finasteride Syndrome

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research Platelet-Rich Plasma and Its Utilities in Alopecia: A Systematic Review

21 citations , June 2019 in “Dermatologic Surgery”

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research Effectiveness and Safety of Low-Dose Oral Minoxidil in Male Androgenetic Alopecia

52 citations , May 2019 in “Journal of The American Academy of Dermatology”

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Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

research Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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research The Effect of the Fractional Carbon Dioxide Laser on Improving Minoxidil Delivery for the Treatment of Androgenetic Alopecia

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research Assessment of Biotin Supplementation Among Patients in an Outpatient Dermatology Clinic

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research The Efficacy and Use of Finasteride in Women: A Systematic Review

23 citations , January 2019 in “International Journal of Dermatology”

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research Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability and the Five C’s of Oral Therapy

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Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

research Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

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A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

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A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss

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Efficacy and Safety of a New 5% Minoxidil Formulation in Male Androgenetic Alopecia: A Randomized, Placebo-Controlled, Double-Blind, Noninferiority Study

research Efficacy and Safety of a New 5% Minoxidil Formulation in Male Androgenetic Alopecia: A Randomized, Placebo-Controlled, Double-Blind, Noninferiority Study

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research The Effectiveness of Adding Low-Level Light Therapy to Minoxidil 5% Solution in the Treatment of Patients with Androgenetic Alopecia

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research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

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research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study

70 citations , February 2017 in “Dermatologic Surgery”

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Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

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136 citations , February 2017 in “International Journal of Molecular Sciences”

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research Platelet-Rich Plasma by Single Spin Process in Male Pattern Androgenetic Alopecia: Is It an Effective Treatment?

27 citations , January 2017 in “Indian Dermatology Online Journal”

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research A Split Head Study of Efficacy of Placebo Versus Platelet-Rich Plasma Injections in the Treatment of Androgenic Alopecia

33 citations , January 2017 in “Journal of Cutaneous and Aesthetic Surgery”

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research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , October 2016 in “Dermatologic Therapy”

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research A Critical Assessment of the Evidence for Low-Level Laser Therapy in the Treatment of Hair Loss

32 citations , September 2016 in “Dermatologic Surgery”

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research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , September 2016 in “Dermatologic Surgery”

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research Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial

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research A 6-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of a Marine Complex Supplement to Promote Hair Growth in Men with Thinning Hair

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The marine complex supplement significantly improved hair growth in men with thinning hair without adverse effects.

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57 citations , July 2016 in “The Journal of Sexual Medicine”

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research Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome

33 citations , January 2016 in “Skin appendage disorders”

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research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

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research Evaluation of Wavelength-Dependent Hair Growth Effects on Low-Level Laser Therapy: An Experimental Animal Study

15 citations , June 2015 in “Lasers in Medical Science”

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A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in Women with Self-Perceived Thinning Hair

research A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in Women with Self-Perceived Thinning Hair

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research Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss

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research Erbium-Yttrium-Aluminum-Garnet Laser Irradiation Ameliorates Skin Permeation and Follicular Delivery of Antialopecia Drugs

31 citations , September 2014 in “Journal of Pharmaceutical Sciences”

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A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

research A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

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Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

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60 citations , May 2014 in “British Journal of Dermatology”

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A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Clinical Effects of Non-Ablative and Ablative Fractional Lasers on Various Hair Disorders: A Case Series of 17 Patients

46 citations , March 2013 in “Journal of Cosmetic and Laser Therapy”

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research Utilizing Electromagnetic Radiation for Hair Growth

12 citations , October 2012 in “Dermatologic Clinics”

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research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

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research The Effect of a 1550 Nm Fractional Erbium-Glass Laser in Female Pattern Hair Loss

47 citations , August 2011 in “Journal of The European Academy of Dermatology and Venereology”

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research Fractional Photothermolysis Laser Treatment of Male Pattern Hair Loss

50 citations , December 2010 in “Dermatologic Surgery”

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research Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia

57 citations , January 2009 in “Indian Journal of Dermatology, Venereology and Leprology”

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research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

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research Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

93 citations , January 2007 in “Skin Pharmacology and Physiology”

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research Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course

30 citations , January 1997 in “Journal of Dermatological Treatment”

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