Noninvasive Hair Rejuvenation

August 2022 in “ Facial Plastic Surgery Clinics of North America ”

Jordan Sand, Scott Walen

androgenetic alopecia minoxidil finasteride low-light laser therapy platelet-rich plasma microneedling antiandrogens prostaglandin analogues adipose injections AGA Rogaine Propecia LLLT PRP

TLDR Noninvasive treatments like minoxidil, finasteride, and low-light laser therapy can help with hair loss.

The document "Noninvasive Hair Rejuvenation" discusses various noninvasive treatment options for androgenetic alopecia (AGA), the most common hair loss disorder in both men and women. The three FDA-approved treatments for AGA are minoxidil, finasteride, and low-light laser therapy (LLLT). Other promising but non-FDA-approved treatments include platelet-rich plasma (PRP) injections, microneedling, antiandrogens, prostaglandin analogues, and adipose injections. Treatments generally take 6 to 12 months to show clinically significant results. The document highlights the need for more rigorous studies on PRP treatments and notes that hair loss can significantly impact self-esteem and quality of life.

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Research cited in this study

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research The Effectiveness of Low-Level Light/Laser Therapy on Hair Loss

8 citations, September 2021 in “Facial plastic surgery & aesthetic medicine”

Low-level light/laser therapy is effective in treating male and female pattern hair loss without side effects.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations, April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research A Study on the Efficacy of Microneedling with Minoxidil Solution Versus Microneedling with Hair Multivitamin Solution for the Treatment of Androgenetic Alopecia

2 citations, March 2020 in “International journal of dermatology and clinical research”

Microneedling helps hair growth, with hair multivitamins showing slightly better results than minoxidil.

research Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature

11 citations, January 2020 in “Skin appendage disorders”

Low-level laser therapy safely and effectively improves hair growth and coverage for male and female pattern hair loss.

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11 citations, December 2019 in “Dermatologic Therapy”

Ketoconazole may help regrow hair and increase follicle size, but more research needed.

The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

38 citations, February 2019 in “Clinical Interventions in Aging”

Dutasteride more effectively treats hair loss than finasteride, but may increase risk of altered libido.

Platelet-Rich Plasma and Microneedling Improve Hair Growth in Patients with Androgenetic Alopecia When Used as an Adjuvant to Minoxidil

research Platelet-Rich Plasma and Microneedling Improve Hair Growth in Patients with Androgenetic Alopecia When Used as an Adjuvant to Minoxidil

24 citations, January 2019 in “Journal of Cosmetic Dermatology”

Combining platelet-rich plasma, microneedling, and minoxidil improves hair growth.

research The Efficacy of Platelet-Rich Plasma in Hair Restoration and Facial Aesthetics: A Systematic Review and Meta-Analysis

31 citations, January 2019 in “Journal of Cutaneous Medicine and Surgery”

Platelet-Rich Plasma (PRP) therapy can promote hair growth and improve facial aesthetics, including reducing acne scars and facial burns, and it works best with three initial monthly injections.

research The Efficacy and Use of Finasteride in Women: A Systematic Review

23 citations, January 2019 in “International Journal of Dermatology”

Finasteride improves hair growth and reduces hirsutism in women, but side effects and optimal dosages need further research.

research Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness?

14 citations, January 2019 in “Skin appendage disorders”

PFS might be a delusional disorder with potential to become mass psychogenic illness.

Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

research Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

36 citations, September 2018 in “American Journal of Clinical Dermatology”

Combination of 0.25% finasteride and 3% minoxidil works better than just 3% minoxidil for increasing hair thickness in women.

A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

research A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

43 citations, July 2018 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.

research A Randomized Controlled, Single-Observer Blinded Study to Determine the Efficacy of Topical Minoxidil Plus Microneedling Versus Topical Minoxidil Alone in the Treatment of Androgenetic Alopecia

24 citations, January 2018 in “Journal of Cutaneous and Aesthetic Surgery”

Combining microneedling with minoxidil is more effective for hair growth than using minoxidil alone.

research Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review

41 citations, December 2017 in “Lasers in Medical Science”

Low-Level Laser Therapy (LLLT) is a safe and effective treatment for common hair loss, but more research is needed to find the best power and wavelength for treatment.

research Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone

80 citations, December 2017 in “International Journal of Dermatology”

Low-dose oral minoxidil and spironolactone combo effectively reduces hair loss and improves hair density in women.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations, November 2017 in “Journal of The European Academy of Dermatology and Venereology”

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research Hormonal Therapy in Female Pattern Hair Loss

21 citations, February 2017 in “International Journal of Women's Dermatology”

Hormonal therapies help treat female hair loss, but results are slow and vary.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations, September 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study

research Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study

33 citations, August 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

Dutasteride is more effective than finasteride at increasing hair count and reversing hair thinning in men with hair loss, but both have similar side effects.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations, April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research Effect of Minoxidil Topical Foam on Frontotemporal and Vertex Androgenetic Alopecia in Men: A 104-Week Open-Label Clinical Trial

20 citations, September 2015 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil foam promotes hair growth and reduces hair loss safely in men.

research Efficacy and Safety of Oral Minoxidil 5 mg Daily During 24-Week Treatment in Male Androgenetic Alopecia

13 citations, May 2015 in “Journal of The American Academy of Dermatology”

Oral minoxidil improves hair growth in men with hair loss, but caution needed for those with heart issues.

research Effect of Dutasteride 0.5 mg/day in Men with Androgenetic Alopecia Recalcitrant to Finasteride

36 citations, June 2014 in “International Journal of Dermatology”

Dutasteride helps hair growth in those unresponsive to finasteride, but may cause more sexual dysfunction.

research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations, February 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

research New Investigational Drugs for Androgenetic Alopecia

48 citations, April 2013 in “Expert Opinion on Investigational Drugs”

Possible new treatments for common hair loss include drugs, stem cells, and improved transplants.

research Finasteride 5 mg/Day Treatment of Patterned Hair Loss in Normo-Androgenetic Postmenopausal Women

44 citations, January 2013 in “International Journal of Trichology”

Finasteride 5 mg/day effectively treats hair loss in postmenopausal women without hyper-androgenism.

research A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study

136 citations, January 2013 in “International Journal of Trichology”

research Platelet-Rich Plasma in Cosmetic Surgery

5 citations, January 2013 in “Otorhinolaryngology clinics : an international journal”

Platelet-rich plasma may improve healing and hair growth in cosmetic surgery but results vary.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations, October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

research A Randomized Double-Blind Placebo-Controlled Pilot Study to Assess the Efficacy of a 24-Week Topical Treatment by Latanoprost 0.1% on Hair Growth and Pigmentation in Healthy Volunteers with Androgenetic Alopecia

81 citations, August 2011 in “Journal of The American Academy of Dermatology”

Latanoprost 0.1% may effectively treat hair loss.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations, October 2010 in “Archives of Dermatology”

Finasteride helps hair growth but may cause sexual side effects.

research 5 mg/Day Finasteride Treatment for Normoandrogenic Asian Women with Female Pattern Hair Loss

64 citations, June 2010 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride improves hair density and thickness in women with hair loss.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations, November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations, October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Treatment of Female Pattern Hair Loss With Oral Antiandrogens

179 citations, March 2005 in “British Journal of Dermatology”

Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.

research Ketoconazole as an Adjunct to Finasteride in the Treatment of Androgenetic Alopecia in Men

28 citations, December 2003 in “Medical Hypotheses”

Ketoconazole shampoo with finasteride improves hair density in men with hair loss.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations, December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations, November 2002 in “Expert Reviews in Molecular Medicine”

Hair loss needs more research for better treatments.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations, November 2000 in “Journal of The American Academy of Dermatology”

Finasteride doesn't effectively treat hair loss in postmenopausal women.

Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women

research Measuring Reversal of Hair Miniaturization in Androgenetic Alopecia by Follicular Counts in Horizontal Sections of Serial Scalp Biopsies: Results of Finasteride 1mg Treatment of Men and Postmenopausal Women

145 citations, December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

Finasteride 1mg helps reverse hair miniaturization in men and postmenopausal women.

research Finasteride

125 citations, January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

research Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

92 citations, January 1998 in “Dermatology”

Ketoconazole shampoo improves hair growth and reduces oil similarly to minoxidil in male pattern hair loss.

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30 citations, January 1997 in “Journal of Dermatological Treatment”

Topical finasteride helps regrow hair and reduce balding without side effects.

research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations, October 1993 in “Journal of The American Academy of Dermatology”

Hair loss affects women's mental health more than men's, causing anxiety, low self-esteem, and social insecurity.

research The Psychological Effects of Androgenetic Alopecia in Men

192 citations, June 1992 in “Journal of The American Academy of Dermatology”

Hair loss can cause low self-esteem, anxiety, and depression in men.

research Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia

67 citations, March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil helps hair growth and prevents hair loss in androgenetic alopecia. It's safe and effective.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations, May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

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86 citations, September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations, September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

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