Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives

The review emphasizes the significant role of mitochondria in hair follicle development and their impact on androgenetic alopecia (AGA). Mitochondrial dysfunction, including energy supply issues and oxidative stress, can impair hair follicle cell growth and differentiation. The study suggests that dihydrotestosterone (DHT) exacerbates hair follicle dysfunction by inducing oxidative stress in mitochondria. It highlights the importance of maintaining mitochondrial function and explores potential therapies, such as mitochondrion-targeting drugs, antioxidants, and low-intensity laser therapy, to address hair loss. Novel drug delivery methods, like microneedle technology, offer precise treatment options. The review underscores the need for further research into mitochondrial functions to develop innovative treatments for hair disorders, offering hope for individuals affected by hair loss.