Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives

February 2025 in “ Stem Cell Research & Therapy ”

Tingru Dong, Yujie Li, Shiyu Jin, Feng Yang, Renxue Xiong, Yun Dai, Xiuzu Song, Cuiping Guan

mitochondria hair follicle androgenetic alopecia mitochondrial dysfunction oxidative stress dihydrotestosterone DHT mitochondrion-targeting drugs antioxidants low-intensity laser therapy microneedle technology AGA hair loss laser therapy

Studysummary This review highlights the critical role of mitochondrial dysfunction in hair loss, particularly androgenetic alopecia, and explores potential therapies targeting mitochondrial pathways to improve hair health, underscoring the need for further research in this area.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review emphasizes the significant role of mitochondria in hair follicle development and their impact on androgenetic alopecia (AGA). Mitochondrial dysfunction, including energy supply issues and oxidative stress, can impair hair follicle cell growth and differentiation. The study suggests that dihydrotestosterone (DHT) exacerbates hair follicle dysfunction by inducing oxidative stress in mitochondria. It highlights the importance of maintaining mitochondrial function and explores potential therapies, such as mitochondrion-targeting drugs, antioxidants, and low-intensity laser therapy, to address hair loss. Novel drug delivery methods, like microneedle technology, offer precise treatment options. The review underscores the need for further research into mitochondrial functions to develop innovative treatments for hair disorders, offering hope for individuals affected by hair loss.

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