Cyclosporine A Increases Hair Follicle Growth by Suppressing Apoptosis-Inducing Factor Nuclear Translocation: A New Mechanism

    January 2015 in “ Fundamental & clinical pharmacology ”
    Shaowei Lan, Feilin Liu, Guifang Zhao … Jin Yu Liu
    Studysummary This study found that cyclosporine A's enhancement of hair growth in mice is partly due to its ability to block the nuclear translocation of apoptosis-inducing factor, slowing the hair follicle transition to the catagen phase.
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    Research cited in this study 10

    1. Cyclosporine A Stimulated Hair Growth from Mouse Vibrissae Follicles in an Organ Culture Model Journal of Nanjing Medical University · 2012
    2. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    3. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    4. Scratching the Surface of Skin Development Nature · 2007
    5. Expression of the Heat Shock Protein-27 in the Adult Human Scalp Skin and Hair Follicle: Hair Cycle–Dependent Changes Journal of the American Academy of Dermatology · 2006
    6. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    7. Cyclosporine-Induced Folliculodystrophy Journal of the American Academy of Dermatology · 2004
    8. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    9. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    10. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

    Related research 2

    1. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    2. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003