Effect of Laser Diode Light Irradiation on Growth Capability of Human Hair Follicle Dermal Papilla Cells

July 2017

S. Jampa-ngern, Kwanchanok Viravaidya-Pasuwat, Saroj Suvanasuthi, Anak Khantachawana

laser diode light human hair follicle dermal papilla cells collagen type 1 Col1 alkaline phosphatase Alp versican Vcan sex determining region y-box 2 Sox2 fibroblast growth factor 7 Fgf7 laser light hair follicle cells collagen FGF7

TLDR Laser diode light boosts hair follicle cell growth and certain gene expressions.

The study investigated the effects of 808 nm laser diode light on the proliferation and gene expression of human hair follicle dermal papilla cells. Cells exposed to light doses higher than 0.5 J/cm² showed increased specific growth rates. Gene expression analysis revealed that while collagen type 1 (Col1), alkaline phosphatase (Alp), and versican (Vcan) did not increase, the sex determining region y-box 2 (Sox2) gene was up-regulated at 0.5 and 1 J/cm², and fibroblast growth factor 7 (Fgf7) gene increased at 0.5, 1, 2.5, and 4 J/cm². Higher doses did not affect gene expression, suggesting an optimal range for laser treatment efficacy.

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Effect of Laser Diode Light Irradiation on Growth Capability of Human Hair Follicle Dermal Papilla Cells

Research cited in this study

research Visible Red Light Enhances Physiological Anagen Entry In Vivo And Has Direct And Indirect Stimulatory Effects In Vitro

research Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

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research Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration

research Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles

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