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GlossaryCollagen XVII (COL17)

protein crucial for skin structure and integrity

Collagen XVII, also known as COL17 or BP180, is a type of protein found in the skin that plays a crucial role in maintaining the structure and integrity of the skin's basement membrane, which separates the outer layer of skin from the underlying layers. It is essential for skin adhesion and wound healing, and its dysfunction can lead to skin blistering diseases such as bullous pemphigoid.

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research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations, February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

research Expression of Anti-Aging Type-XVII Collagen (COL17A1/BP180) in Hair Follicle-Associated Pluripotent (HAP) Stem Cells During Differentiation

11 citations, June 2019 in “Tissue & Cell”

Hair stem cells produce a protein called COL17A1 that plays a key role in their development and is linked to hair thinning and baldness.

research Signature Selection Analysis Reveals Candidate Genes Associated With Production Traits in Iranian Sheep Breeds

55 citations, December 2021 in “BMC Veterinary Research”

Certain genes in Iranian sheep are linked to wool production and heat adaptation.

research Identification of Sirtuin 1 as a Promising Therapeutic Target for Hypertrophic Scars

36 citations, February 2016 in “British journal of pharmacology”

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

research TGF-β2 and Collagen Play Pivotal Roles in the Spheroid Formation and Anti-Aging of Human Dermal Papilla Cells

11 citations, August 2021 in “Aging”

Collagen and TGF-β2 help maintain hair cell shape and youthfulness.

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community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

in Treatments 309 upvotes 6 months ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community What should I expect from dutasteride?

in Finasteride/Dutasteride 2 upvotes 3 years ago

The user tried Minoxidil, PRP, Hair Carboxytherapy, and topical Dutasteride with limited success and is now on oral Dutasteride. They are experiencing some hair loss reduction but no significant density improvement, leading to feelings of depression.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 6 upvotes 7 months ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community Stop expecting results in 2 months!

in Treatment 125 upvotes 7 months ago

People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.