Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model

    January 2022 in “ Stem cell reviews and reports ”
    Hanluo Li, Mirjana Ziemer, Ivana Stojanović, Tamara Saksida, Danijela Maksimović‐Ivanić, Sanja Mijatović, Goran Djmura, Dragica Gajić, Ivan Koprivica, Tamara Krajnović, Dijana Drača, Jan‐Christoph Simon, Bernd Lethaus, Vuk Savković
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    TLDR Mouse stem cells from hair follicles can improve wound healing and reduce scarring.
    In a study aimed at improving wound healing and reducing hypertrophic scarring, mesenchymal stem cells (moMSCORS) isolated from the outer root sheath of mouse whisker hair follicles were used in a full-thickness wound model in C57BL/6 mice. These cells were expanded and characterized in vitro, meeting the criteria for mesenchymal stem cells. When applied to wounds, moMSCORS-treated wounds exhibited less inflammation, faster wound closure, and reduced hypertrophic scarring compared to untreated wounds. This was evidenced by clinical scoring, software-based quantification, and histological staining, which showed lower cellularity, fewer collagen filaments, and thinner dermal and epidermal layers in treated wounds. The study demonstrates the potential of moMSCORS in autologous cell therapy for wound healing and offers a viable in vivo model for further research.
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