Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model

    January 2022 in “ Stem cell reviews and reports ”
    Hanluo Li, Mirjana Ziemer, Ivana Stojanović, Tamara Saksida, Danijela Maksimović‐Ivanić, Sanja Mijatović, Goran Djmura, Dragica Gajić, Ivan Koprivica, Tamara Krajnović, Dijana Drača, Jan‐Christoph Simon, Bernd Lethaus, Vuk Savković
    Image of study
    TLDR Mouse stem cells from hair follicles can improve wound healing and reduce scarring.
    In a study aimed at improving wound healing and reducing hypertrophic scarring, mesenchymal stem cells (moMSCORS) isolated from the outer root sheath of mouse whisker hair follicles were used in a full-thickness wound model in C57BL/6 mice. These cells were expanded and characterized in vitro, meeting the criteria for mesenchymal stem cells. When applied to wounds, moMSCORS-treated wounds exhibited less inflammation, faster wound closure, and reduced hypertrophic scarring compared to untreated wounds. This was evidenced by clinical scoring, software-based quantification, and histological staining, which showed lower cellularity, fewer collagen filaments, and thinner dermal and epidermal layers in treated wounds. The study demonstrates the potential of moMSCORS in autologous cell therapy for wound healing and offers a viable in vivo model for further research.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 15 results

      community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

      in Progress Pictures  27 upvotes 1 year ago
      A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 2 years ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 3 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

    Similar Research

    5 / 1000+ results