Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes

The study demonstrates that mesenchymal stem cells derived from mouse hair follicles (moMSCORS) can inhibit the development of Type 1 Diabetes (T1D) in C57BL/6 mice. The intravenous administration of moMSCORS significantly reduced blood glucose levels, T1D incidence, and insulitis in pancreatic islets. The treatment modulated immune responses by decreasing pro-inflammatory cytokines like IFN-γ and IL-17 and altering immune cell populations, such as reducing Th17 and IFN-γ+ CD8+ T cells while increasing regulatory T cells (Tregs). The study involved six animals per group, with statistically significant results (p < 0.05), highlighting moMSCORS as a promising therapeutic candidate for T1D due to their non-invasive collection and immunosuppressive effects.