Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes

May 2024 in “ International Journal of Molecular Sciences ”

Dragica Mićanović, Suzana Stanisavljević, Hanluo Li, Ivan Koprivica, Natalija Jonić, Ivana Stojanović, Vuk Savković, Tamara Saksida

mesenchymal stem cells hair follicles cytokines immune responses regulatory T cells Th17 cells CD8+ T cells

TLDR Mouse hair follicle stem cells can help prevent Type 1 Diabetes.

The study demonstrates that mesenchymal stem cells derived from mouse hair follicles (moMSCORS) can inhibit the development of Type 1 Diabetes (T1D) in C57BL/6 mice. The intravenous administration of moMSCORS significantly reduced blood glucose levels, T1D incidence, and insulitis in pancreatic islets. The treatment modulated immune responses by decreasing pro-inflammatory cytokines like IFN-γ and IL-17 and altering immune cell populations, such as reducing Th17 and IFN-γ+ CD8+ T cells while increasing regulatory T cells (Tregs). The study involved six animals per group, with statistically significant results (p < 0.05), highlighting moMSCORS as a promising therapeutic candidate for T1D due to their non-invasive collection and immunosuppressive effects.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

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community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

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