TLDR Adipose-derived stem cells are promising for regenerative medicine due to their accessibility, versatility, and low risk of immune rejection.
The document reviewed the regenerative potential of adipose-derived stem cells (ADSCs) compared to mesenchymal stem cells (MSCs) from bone marrow and umbilical cord sources. ADSCs were noted for their accessibility, abundance, and ability to differentiate into various cell types, making them suitable for regenerative medicine. They showed promise in treating neurodegenerative, cardiovascular, and autoimmune diseases, as well as in applications like wound healing and hair growth. ADSCs exhibited low immunogenicity, allowing for potential allogeneic transplantation without immunosuppression. Despite their advantages, challenges such as long-term culture effects and standardization for clinical use remained. Overall, ADSCs demonstrated significant regenerative capabilities, particularly through paracrine effects, across various medical applications.
45 citations
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May 2018 in “Stem Cell Research & Therapy” Using patients' own fat-derived cells to treat alopecia areata significantly improved hair growth and was safe.
83 citations
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March 2015 in “International Journal of Dermatology” ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.
53 citations
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April 2016 in “Stem cell research & therapy” LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.
43 citations
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January 2011 in “Plastic and Reconstructive Surgery” Stem cells have great potential for improving wound healing, but more research is needed to find the best types and ways to use them.
65 citations
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June 2020 in “Stem Cell Research & Therapy” Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
7 citations
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March 2017 in “Actas Dermo-Sifiliográficas” Several new treatments for different types of hair loss show promise in improving patient quality of life.
136 citations
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May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
132 citations
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January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
