Novel Complex of Cosmetic Ingredients with Promising Action in Preventing Hair Loss and Follicular Aging Through Mechanism Involving Enrichment of WNT/Signaling, Mitochondrial Activity, and Stem Cells Maintenance

    November 2020 in “ Journal of Cosmetic Dermatology ”
    Mamy Honda Igarashi, Sheila Gomes da Silva, Maurízio Mercuri … Samara Eberlin
    Studysummary This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.
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    Research cited in this study 11

    1. Efficacy and Safety of a New Formulation Kit (Shampoo + Lotion) Containing Anti-Inflammatory and Antioxidant Agents to Treat Hair Loss Dermatologic Therapy · 2020
    2. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    3. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    4. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    5. Baicalin, A Flavonoid, Affects The Activity Of Human Dermal Papilla Cells And Promotes Anagen Induction In Mice Naunyn-Schmiedeberg's Archives of Pharmacology · 2014
    6. The Inhibitory Effect of Scutellaria Baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia Planta Medica · 2014
    7. What Women Want: Quantifying the Perception of Hair Amount - An Analysis of Hair Diameter and Density Changes with Age in Caucasian Women British Journal of Dermatology · 2012
    8. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    9. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    10. Androgen Action on Human Skin – From Basic Research to Clinical Significance Experimental dermatology · 2004
    11. Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

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