Novel Complex of Cosmetic Ingredients with Promising Action in Preventing Hair Loss and Follicular Aging Through Mechanism Involving Enrichment of WNT/Signaling, Mitochondrial Activity, and Stem Cells Maintenance

November 2020 in “ Journal of Cosmetic Dermatology ”

Mamy Honda Igarashi, Sheila Gomes da Silva, Maurízio Mercuri, Flávia Macedo de Oliveira Neves Zuardi, Gustavo Facchini, Gustavo Henrique da Silva, Ana Lúcia Tabarini Alves Pinheiro, Samara Eberlin

The study explored the effects of a complex of nanoencapsulated active ingredients (AcPi) and its cosmetic formulations (ShPi and HtPi) on hair loss and follicular aging. The research involved treating human hair follicle dermal papilla cells and human scalp cultures with these ingredients, followed by exposure to UV radiation or testosterone. Results indicated that AcPi prevented oxidative stress and balanced mitochondrial activity, enriched the WNT/β-catenin signaling pathway to stimulate hair growth, and extended the anagen phase of the hair cycle. ShPi and HtPi minimized degradation of COL17A1 and controlled androgenic metabolism by reducing DHT production. Although the full effects of AcPi were not completely understood, the findings suggested it could prevent follicular aging and hair loss through mechanisms involving energetic homeostasis, antioxidant, and anti-androgenic actions.

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