Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis

    July 2017 in “ eLife ”
    Mika Watanabe, Ken Natsuga, Wataru Nishie … Hiroshi Shimizu
    Studysummary This study found that COL17 deficiency in neonatal mice causes abnormal skin cell proliferation due to disrupted Wnt signaling, while replenishing or overexpressing COL17 can reverse this effect in both neonatal and aged skin.
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    Research cited in this study 11

    1. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    2. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015
    3. Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy Cell death and differentiation · 2015
    4. Epidermal Polarity Genes in Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014
    5. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    6. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    7. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014
    8. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    9. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    10. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007
    11. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002

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