TLDR Mitochondrial reactive oxygen species are essential for skin and hair development.
The study from February 5, 2013, concluded that mitochondrial reactive oxygen species (ROS) were crucial for epidermal differentiation and hair follicle development. Researchers found that mice with a keratinocyte-specific deficiency in mitochondrial transcription factor A (TFAM) exhibited impaired epidermal differentiation and hair follicle growth, which could be partially rescued with exogenous hydrogen peroxide. The study highlighted the necessity of mitochondrial ROS for Notch and β-catenin signaling, essential for these processes, and suggested potential therapeutic targets for hair growth and skin differentiation conditions.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
375 citations,
February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
September 2017 in “Asian Journal of Beauty and Cosmetology” The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.
8 citations,
May 2021 in “Bioengineering & translational medicine” Hair growth environment recreated with challenges; stem cells make successful skin organoids.
18 citations,
October 2018 in “Nutrients” Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.
76 citations,
June 2015 in “Journal of biomedical science” Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
30 citations,
July 2017 in “BioEssays” Activating NRF2 might help treat hair disorders by improving antioxidant defenses.
