Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

May 2020 in “ Journal of visualized experiments ”

Jesús Espada, Elisa Carrasco, María I. Calvo-Sánchez, Sandra Fernández-Martos, Juan José Montoya

stem cell niches tissue regeneration reactive oxygen species ROS hair follicle growth photodynamic treatment protoporphyrin IX red light irradiation stem cells tissue repair hair growth light therapy PpIX red light therapy

TLDR Controlled light treatment in mouse skin speeds up healing and hair growth.

The study described a protocol for inducing switchable in vivo photogeneration of endogenous reactive oxygen species (ROS) in mouse skin, which efficiently activated cell proliferation in stem cell niches and stimulated tissue regeneration. This was demonstrated by accelerated burn healing and hair follicle growth. The protocol involved a regulatable photodynamic treatment using precursors of the endogenous photosensitizer protoporphyrin IX and red light irradiation under controlled conditions, providing a valuable tool for analyzing ROS biology.

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