Protective Effect of Iris Germanica L. Rhizome-Derived Exosome Against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes

October 2023 in “ Applied sciences ”

Jinhyun Kim, Hyun-Jeong Lee, Eun-Jeong Yoon, Hyunsang Lee, You Ji, Young-Seok Kim, Sijun Park, Junoh Kim, Seunghee Bae

Iris germanica L. rhizome-derived exosomes oxidative stress cellular senescence human epidermal keratinocytes reactive oxygen species antioxidant enzyme senescence-associated β-galactosidase cell cycle arrest marker p21 wound-healing properties keratinization markers keratin 1 keratin 10 Iris-exosomes ROS SA-β-gal p21

TLDR Iris germanica rhizome-derived exosomes help protect skin cells from oxidative stress and aging.

The study demonstrates that exosomes derived from Iris germanica L. rhizomes exhibit significant antioxidant and anti-senescence properties in human epidermal keratinocytes (nHEKs). These exosomes, characterized by Cryo-TEM and NTA, improve cell viability, reduce oxidative stress, and decrease cellular senescence markers when nHEKs are exposed to H2O2. They upregulate antioxidant enzymes (HO-1, CAT, GSS, GPx1, and SOD) and modulate the p38/JNK MAPK pathway to lower p53 and p21 levels. Additionally, Iris-exosomes enhance keratinocyte barrier function and wound healing, suggesting potential therapeutic applications for skin aging and oxidative stress-related conditions.

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Protective Effect of Iris Germanica L. Rhizome-Derived Exosome Against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes

Research cited in this study

research OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

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