Notch Signaling in Hair Follicle Development

September 2017 in “ Asian Journal of Beauty and Cosmetology ”

Seunghee Bae, Lee Ki Heon, 이인호, 김미경, Jae Ho Lee

Notch signaling pathway hair follicle development stem cell homeostasis hair follicle stem cells hair cycles hair bulb Musashi family neural stem/progenitor cells reactive oxygen species ROS Tspear Leptin

TLDR The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.

The 2017 document reviewed the Notch signaling pathway's role in hair follicle development. The Notch pathway, a significant signal transduction route, regulates stem cell homeostasis and development in multicellular organisms, including hair follicles. It is crucial in determining cell fate during hair follicle development, controlling hair follicle stem cell fates, regulating hair cycles, and resuscitating injured hair organs. The Notch signaling pathway also regulates hair follicle stem cell differentiation in the hair bulb. The document also discussed the Musashi (Msi) family's role in maintaining neural stem/progenitor cells' stem cell status and their interaction with the Notch signaling pathway. The review also highlighted three factors that may influence Notch signaling: reactive oxygen species (ROS), Tspear, and Leptin. The review concluded that understanding the Notch signaling pathway's role in hair follicle development could lead to potential stem cell-based therapeutics for hair follicle abnormalities.

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research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

40 citations , July 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Growing hair follicles have high mitochondrial activity and ROS in specific regions, aiding hair formation.

research Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hedgehog Signaling Pathway

29 citations , May 2017 in “Journal of Investigative Dermatology”

The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.

research Signaling Involved in Hair Follicle Morphogenesis and Development

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The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Hair Cycle Control by Leptin as a New Anagen Inducer

41 citations , December 2013 in “Experimental Dermatology”

Leptin, a hormone, is important for starting hair growth.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations , October 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations , January 2011 in “PloS one”

Notch signaling is essential for healthy skin and hair follicle maintenance.

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

67 citations , February 2009 in “Developmental Biology”

Msx2 and Foxn1 are both crucial for hair growth and health.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , November 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

62 citations , January 2000 in “Developmental dynamics”

Notch-related genes play a key role in the development and cycling of hair follicles.

research Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

1 / 1 results

research Mouse notch: expression in hair follicles correlates with cell fate determination.

150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

Mouse Notch is important for determining cell roles in hair follicles.