Notch Signaling in Hair Follicle Development

September 2017 in “ Asian Journal of Beauty and Cosmetology ”

Seunghee Bae, Lee Ki Heon, 이인호, 김미경, Jae Ho Lee

Notch signaling pathway hair follicle development stem cell homeostasis hair follicle stem cells hair cycles hair bulb Musashi family neural stem/progenitor cells reactive oxygen species ROS Tspear Leptin

TLDR The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.

The 2017 document reviewed the Notch signaling pathway's role in hair follicle development. The Notch pathway, a significant signal transduction route, regulates stem cell homeostasis and development in multicellular organisms, including hair follicles. It is crucial in determining cell fate during hair follicle development, controlling hair follicle stem cell fates, regulating hair cycles, and resuscitating injured hair organs. The Notch signaling pathway also regulates hair follicle stem cell differentiation in the hair bulb. The document also discussed the Musashi (Msi) family's role in maintaining neural stem/progenitor cells' stem cell status and their interaction with the Notch signaling pathway. The review also highlighted three factors that may influence Notch signaling: reactive oxygen species (ROS), Tspear, and Leptin. The review concluded that understanding the Notch signaling pathway's role in hair follicle development could lead to potential stem cell-based therapeutics for hair follicle abnormalities.

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Research cited in this study

16 / 16 results

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The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

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Leptin, a hormone, is important for starting hair growth.

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Mitochondrial reactive oxygen species are essential for skin and hair development.

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Hair growth and development are controlled by specific signaling pathways.

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Notch signaling is essential for healthy skin and hair follicle maintenance.

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Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

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67 citations , December 2008 in “Developmental Biology”

Msx2 and Foxn1 are both crucial for hair growth and health.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

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Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

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Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

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Caffeine can stimulate hair growth and counteract testosterone's suppressive effects on hair follicles.

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Notch-related genes play a key role in the development and cycling of hair follicles.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

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Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

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Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.

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research Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination

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Mouse Notch is important for determining cell roles in hair follicles.