Absence of Vitamin D Receptor-Mediated PPARγ Suppression Causes Alopecia in VDR-Null Mice
December 2016
in “
The FASEB Journal
”
Research cited in this study
21 / 21 resultsresearch Foxc1 reinforces quiescence in self-renewing hair follicle stem cells
research The Vitamin D Receptor Is Required for Activation of CWnt and Hedgehog Signaling in Keratinocytes
research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia
Researchers created a mouse model of a type of rickets that does not cause hair loss.
research Emerging Interactions Between Skin Stem Cells and Their Niches
Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
research Potential Relationship Between the Canonical Wnt Signaling Pathway and Expression of the Vitamin D Receptor in Alopecia
Targeting the Wnt pathway might help treat hair loss.
research Mutations in the Vitamin D Receptor and Hereditary Vitamin D-Resistant Rickets
Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.
research Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ
Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Fat-related cells are important for initiating hair growth.
research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor
LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.
research Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice
Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.
research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis
Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.
research Vitamin D receptor is essential for normal keratinocyte stem cell function
Vitamin D receptor is crucial for normal hair growth and preventing hair loss.
research Hair follicle expression of 1,25-dihydroxyvitamin D3 receptors during the murine hair cycle
research The Hair Cycle
The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
research Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis
research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
The study investigated the effects of repressing β-catenin/Lef1 signalling in mouse epidermis by expressing a ΔNLef1 transgene. Mice showed no skin abnormalities before the first postnatal hair cycle, but from 6 weeks of age, they experienced progressive hair loss and developed dermal cysts originating from hair follicles. These cysts expressed markers of interfollicular epidermis. Adult mice spontaneously developed skin tumours, mostly with sebaceous differentiation, suggesting an origin in the upper hair follicle. The transgene was expressed in the tumours, inhibiting β-catenin signalling, as shown by the absence of cyclin D1 expression, while patched mRNA was upregulated, implicating the sonic hedgehog pathway in tumour formation. The study concluded that β-catenin signalling levels determine keratinocyte differentiation into hair or interfollicular epidermis, and that ΔNLef1 overexpression can lead to skin tumours.
research Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia
research Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice
research Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice*
research Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice
research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice
Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.