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research The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor

4 citations , February 2023 in “International Journal of Stem Cells”

The FTO gene hinders stem cells in hair follicles from becoming pigment cells.

Transcription Factor SOX2-Induced Amphiregulin Inhibits Pressure Ulcer Formation via Suppressing Oxidative Stress After Cutaneous Ischemia-Reperfusion in Mice

research 1496 Transcription factor SOX2-induced amphiregulin inhibits pressure ulcer formation via suppressing oxidative stress after cutaneous ischemia-reperfusion in mice

April 2023 in “Journal of Investigative Dermatology”

This study found that inducing SOX2 in keratinocytes significantly reduced pressure ulcer formation after cutaneous ischemia-reperfusion injury by producing amphiregulin, which also reduced oxidative stress and apoptosis.

research Absence of vitamin D receptor (VDR)‐mediated PPARγ suppression causes alopecia in VDR‐null mice

12 citations , December 2016 in “The FASEB Journal”

This study found that the absence of vitamin D receptor-mediated suppression of PPARγ expression causes hair loss in VDR-null mice.

research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

19 citations , December 2015 in “Journal of Investigative Dermatology”

This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.

research Minoxidil may suppress androgen receptor-related functions

24 citations , April 2014 in “Oncotarget”

This study found that minoxidil suppressed androgen receptor functions and stability, suggesting its potential use in treating diseases related to the androgen-AR pathway.

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community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Testosterone in Reference Range Doesn't Cause Hair Loss

52 upvotes 2 years ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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