Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

    Aditya K. Gupta, Tong Wang, Shruthi Polla Ravi … Antonella Tosti
    Studysummary This review suggests that oral Janus kinase inhibitors are a promising treatment for alopecia areata in adults, showing significant hair regrowth with fewer side effects than conventional treatments, while PDE-4 inhibitors and biologics show limited efficacy.
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    Research cited in this study 28

    1. Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels Frontiers in immunology · 2022
    2. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    3. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021
    4. Alopecia Areata and Tofacitinib: A Prospective Multicenter Study from a Saudi Population International Journal of Dermatology · 2021
    5. Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study Journal of The American Academy of Dermatology · 2021
    6. Sublingual Tofacitinib for Alopecia Areata: A Roll-Over Pilot Clinical Trial and Analysis of Pharmacokinetics International Journal of Dermatology · 2021
    7. A Phase 2a Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of the Oral Janus Kinase Inhibitors Ritlecitinib and Brepocitinib in Alopecia Areata: 24-Week Results Journal of the American Academy of Dermatology · 2021
    8. Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review Journal of Investigative Dermatology Symposium Proceedings · 2020
    9. Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing Its Impact on T Regulatory Cell and NK Cell Populations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2020
    10. Apremilast for Extensive and Treatment-Resistant Alopecia Areata: A Retrospective Analysis of Five Patients European Journal of Dermatology · 2020
    11. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    12. Reactivation of Alopecia Areata After Dupilumab Therapy for Atopic Dermatitis Dermatitis · 2019
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    14. Dupilumab And Alopecia: A Janus Effect Dermatologic Therapy · 2019
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    20. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018
    21. Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata Journal of the American Academy of Dermatology · 2017
    22. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
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    26. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
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    Related research 4

    1. Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata Dermatology Reports · 2022
    2. Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata Dermatology Reports · 2021
    3. Early Onset of Alopecia Areata After Dupilumab Introduction in a Patient With Atopic Dermatitis European Journal of Dermatology · 2019
    4. Dupilumab Improved Alopecia Areata in a Patient with Atopic Dermatitis: A Case Report Acta Dermato Venereologica · 2019