Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

    December 2022 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”
    Aditya K. Gupta, Tong Wang, Shruthi Polla Ravi, Mary Bamimore, Vincent Piguet, Antonella Tosti
    Image of study
    TLDR New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.
    This systematic review evaluates newer agents for treating moderate-to-severe alopecia areata (AA) in adults, focusing on Janus kinase (JAK) inhibitors, biologics, and phosphodiesterase-4 (PDE-4) inhibitors. The review included 12 randomized controlled trials (RCTs) identified from 106 items in PubMed and ClinicalTrials.gov. The findings suggest that oral JAK inhibitors (baricitinib, ritlecitinib, deuruxolitinib, brepocitinib) show significant promise in inducing hair regrowth with mild to moderate adverse effects. Baricitinib has received US FDA approval for severe AA, while ritlecitinib and deuruxolitinib have breakthrough therapy designations. In contrast, PDE-4 inhibitors (apremilast) and biologics (dupilumab, secukinumab, aldesleukin) have shown limited efficacy. Ongoing and future long-term studies are needed to further understand the potential of these newer agents in managing AA.
    Discuss this study in the Community →

    Research cited in this study

    25 / 25 results

    Related Community Posts Join

    6 / 1000+ results

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 8 months apart on the mother of all stacks

      in Progress Pictures  149 upvotes 1 year ago
      User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 5 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    3 / 3 results