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GlossaryPDE4 inhibitors

block an enzyme to reduce inflammation and immune responses

PDE4 inhibitors, also known as Phosphodiesterase 4 inhibitors or PDE4i, are a class of drugs that block the enzyme phosphodiesterase 4. This enzyme is involved in breaking down cyclic adenosine monophosphate (cAMP), a molecule that plays a crucial role in regulating inflammation and immune responses. By inhibiting PDE4, these drugs can help reduce inflammation and are used to treat conditions like psoriasis, chronic obstructive pulmonary disease (COPD), and certain types of alopecia.

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Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

research Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

12 citations, December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.

research 22-Year-Old Male with Several Discrete Patches of Hair Loss

January 2022 in “Clinical Cases in Dermatology”

A 22-year-old man has alopecia areata, an autoimmune hair loss condition, with various treatments available.

research Treatment of Alopecia Areata and Its Numerous Possibilities: A Literature Review

October 2024 in “Journal of Education Health and Sport”

Alopecia areata treatment should be personalized, using topical or systemic therapies based on severity, with promising options like JAK inhibitors needing more research.

The Relative Efficacy of Monotherapy With Janus Kinase Inhibitors, Dupilumab and Apremilast in Adults With Alopecia Areata: Network Meta-Analyses of Clinical Trials

research The Relative Efficacy of Monotherapy With Janus Kinase Inhibitors, Dupilumab and Apremilast in Adults With Alopecia Areata: Network Meta-Analyses of Clinical Trials

2 citations, July 2023 in “Journal of cosmetic dermatology”

JAK inhibitors are more effective and safer for treating alopecia areata than dupilumab and apremilast.

research Cytokine-Targeted Treatment in Alopecia Areata - New Possibilities?

1 citations, May 2023 in “Prospects in Pharmaceutical Sciences”

New cytokine-targeted therapies show promise for treating alopecia areata.

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community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways

in Research/Science 2 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.