Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice

September 2019 in “ International Journal of Nanomedicine ”

Noriaki Nagai, Yoshie Iwai, Akane Sakamoto, Hiroko Otake, Yoshihiro Oaku, Akinari Abe, Tohru Nagahama

minoxidil nanoparticles N-MXD C57BL/6 mice hair bulbs commercially available minoxidil formulations CA-MXD hair growth factors insulin-like growth factor-1 IGF-1 vascular endothelial growth factor VEGF Rogaine mice commercial minoxidil growth factors

TLDR Minoxidil nanoparticles can potentially be a more effective treatment for hair growth than current treatments.

In 2019, a study was conducted to test a new drug delivery system based on minoxidil nanoparticles (N-MXD) for promoting hair growth in C57BL/6 mice. The study found that N-MXD delivered minoxidil into hair bulbs more effectively than commercially available minoxidil formulations (CA-MXD), resulting in higher minoxidil content in the hair bulbs and lower content in the skin tissue. The therapeutic efficiency for hair growth was also higher for N-MXD than for CA-MXD. Additionally, the levels of hair growth factors, insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF), were significantly higher in mice treated with N-MXD. The study concluded that N-MXD could potentially be a more effective treatment for hair growth than current commercially available treatments.

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