Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles

January 2015 in “ International Journal of Biological Macromolecules ”

Breno N. Matos, Thaiene Avila Reis, Tais Gratieri

chitosan nanoparticles minoxidil sulphate MXS-NP hair follicles alopecia follicular accumulation topical treatment minoxidil Rogaine

TLDR Chitosan nanoparticles improve minoxidil delivery to hair follicles for better alopecia treatment.

The study developed chitosan nanoparticles loaded with minoxidil sulphate (MXS-NP) for targeted delivery to hair follicles, which could sustain drug release and improve the topical treatment of alopecia. The MXS-NP formulation was found to be superior to previously prepared MXS-loaded microparticles in terms of follicular accumulation of MXS and prolonged release of the drug into hair follicles. The study suggests that chitosan nanoparticles could be a promising strategy for the topical treatment of alopecia.

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Research cited in this study

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Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles

Research cited in this study

research Delivery and Targeting of Nanoparticles into Hair Follicles

research Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells

research Iontophoresis-Targeted, Follicular Delivery of Minoxidil Sulfate for the Treatment of Alopecia

research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil: In Vitro Evaluation of Drug Permeation by Infrared Spectroscopy

research Chitosan Microparticles for Sustaining the Topical Delivery of Minoxidil Sulphate

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Selective Follicular Targeting by Modification of the Particle Sizes

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

research Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles

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