Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil: In Vitro Evaluation of Drug Permeation by Infrared Spectroscopy

May 2012 in “ Pharmaceutical Development and Technology ”

Simona Mura, Maria Manconi, Anna Maria Fadda, Maria Sala, Jacopo Perricci, Elena Pini, Chiara Sinico

penetration enhancer-containing vesicles PEVs cutaneous delivery minoxidil infrared spectroscopy FTIR spectroscopy drug permeation deformable vesicles drug depot skin delivery Rogaine FTIR drug absorption flexible vesicles drug storage

Studysummary PEVs effectively deliver minoxidil through skin. Our plain-language summary of this paper — not a Tressless recommendation.

The study evaluated the use of penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil. The results showed that the introduction of PE in the vesicular formulation led to deformable vesicles able to penetrate deeply in the skin with a formation of a drug depot. FTIR spectroscopy was used to analyze the vesicular formulations and to study the diffusion and distribution of MX in the skin. The study concluded that PEVs can be used as effective carriers for cutaneous delivery of minoxidil.

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research Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil

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This study found that liposomal formulations improved minoxidil delivery to skin layers compared to niosomes and a control solution, suggesting enhanced potential for topical hair loss treatment.

research Minoxidil: Mechanisms of Action on Hair Growth

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