Penetration Enhancer-Containing Vesicles as Carriers for Cutaneous Delivery of Minoxidil: In Vitro Evaluation of Drug Permeation by Infrared Spectroscopy

The study evaluated the use of penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil. The results showed that the introduction of PE in the vesicular formulation led to deformable vesicles able to penetrate deeply in the skin with a formation of a drug depot. FTIR spectroscopy was used to analyze the vesicular formulations and to study the diffusion and distribution of MX in the skin. The study concluded that PEVs can be used as effective carriers for cutaneous delivery of minoxidil.