Study on Transdermal Permeation and Skin Accumulation of Finasteride Ethosomes

January 2004 in “ Zhōnghuá yàoxué zázhì ”

Wenquan Liang

finasteride ethosomes liposomes transdermal penetration Franz diffusion cells hydroethanolic solution Propecia

TLDR Ethosomes improve skin absorption of finasteride more than other methods.

The study investigated the transdermal penetration characteristics of finasteride ethosomes. Finasteride ethosomes were compared to liposomes and other solutions using human skin in modified Franz diffusion cells. The results showed that the penetration rate of finasteride from ethosomes was significantly higher—6.4 times greater than from a saturated water solution, 2.2 times greater than from liposomes, and 1.6 times greater than from a hydroethanolic solution. Additionally, the amount of finasteride accumulated in the skin was greater with ethosomes. The study concluded that ethosomes enhanced the transdermal permeation and skin accumulation of finasteride.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community How does low level laser therapy?

in Chat 5 upvotes 8 months ago

Low-level laser therapy (LLLT) is debated for hair regrowth, with some users suggesting it should be combined with treatments like minoxidil and finasteride for effectiveness. Many users express skepticism about LLLT's efficacy and cost, emphasizing the need for the correct wavelength and quality devices.

community Is there a 50 year old "young old man" here who started oral fina at 0.1 mg to maintain his hair?

in Finasteride/Dutasteride 2 upvotes 1 year ago

A person experienced side effects from topical finasteride and is now trying a low dose of oral finasteride (0.1mg) for hair maintenance, alongside topical minoxidil, Fluridil, CosmeRNA, and exosomes. They are also taking resveratrol and nettle leaf to mitigate side effects.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

in Finasteride/Dutasteride 34 upvotes 2 years ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community I cry every day, everything is very depressing

in Finasteride/Dutasteride 52 upvotes 8 months ago

A user is experiencing hair loss despite using dutasteride and oral minoxidil, feeling hopeless and considering a hair system. They are advised to try ketoconazole, seek a second opinion from a dermatologist, and consider treatments like finasteride, RU58841, and hair transplants.

community find a cure for this shit already

in Chat 208 upvotes 5 years ago

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

community Why don't do it yourself topical solutions not talk about ethosomes as delivery mechanism?

in Treatment 4 upvotes 4 weeks ago

Ethosomes are suggested as an effective delivery method for topical finasteride solutions, requiring the addition of a phospholipid like soya lecithins. The user questions why do-it-yourself solutions don't commonly use ethosomes despite their potential benefits.

Related Research

4 / 4 results

research Penetration Profile and Human Cadaver Skin Distribution of Finasteride from Vesicular Nanocarriers

9 citations , October 2013 in “Drug Delivery”

Ethosomal carriers effectively deliver hair loss drug into skin.

research Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes

11 citations , April 2011 in “Biomolecules & Therapeutics”

Anionic liposome formulations of finasteride may effectively treat hair loss with fewer side effects.

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

84 citations , July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.

research Influence of Liposomes and Niosomes on the In Vitro Permeation and Skin Retention of Finasteride

3 citations , March 2005 in “Iranian Journal of Pharmaceutical Sciences”

Liposomes and niosomes can increase finasteride retention in the skin.