In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

July 2008 in “ Aaps Pharmscitech ”

Yuefeng Rao, Feiyue Zheng, Xingang Zhang, Jian-Qing Gao, Wen-Quan Liang

finasteride transdermal drug delivery system ethosomes vesicular carriers percutaneous absorption human cadaver skin Propecia

TLDR Ethosomes improve finasteride delivery through skin for hair loss treatment.

This study aimed to develop a transdermal drug delivery system for finasteride, a medication used to treat hair loss. The researchers found that ethosomes, a type of vesicular carrier, were more efficient delivery carriers with high encapsulation capacities and significantly increased the permeation of finasteride through human cadaver skin. Ethosomes also produced a significant finasteride accumulation in the skin, especially in deeper layers, making them promising vesicular carriers for enhancing percutaneous absorption of finasteride. The study suggests that ethosomal carriers could be a suitable transdermal drug delivery system for finasteride.

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Research cited in this study

2 / 2 results

research Ethosomes: New Prospects in Transdermal Delivery

222 citations, January 2003 in “Critical Reviews in Therapeutic Drug Carrier Systems”

Ethosomes can safely and effectively deliver various drugs deep into the skin.

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Ethosomal carriers improve drug delivery through the skin better than traditional methods.

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research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

84 citations, July 2008 in “Aaps Pharmscitech”

Ethosomes improve finasteride delivery through skin for hair loss treatment.