Enhanced Delivery of Drugs Into and Across the Skin by Ethosomal Carriers
January 2000
in “
Drug Development Research
”
ethosomal carriers phospholipid vesicular systems dermal drug delivery transdermal drug delivery lipophilic molecules hydrophilic molecules ethosomal formulations aciclovir herpes labialis ethosomal patches testosterone commercial patches antiparkinsonian treatment trihexyphenidyl hydrochloride ethosomal delivery insulin blood glucose levels ethosomes liposomes skin drug delivery transdermal patches testosterone patches herpes treatment Parkinson's treatment blood sugar levels
TLDR Ethosomal carriers improve drug delivery through the skin better than traditional methods.
Ethosomal carriers, which are phospholipid vesicular systems with high alcohol content, were found to significantly enhance dermal and transdermal drug delivery compared to classic liposomal systems. They effectively delivered both lipophilic and hydrophilic molecules deep into the skin. Clinical studies showed that ethosomal formulations of aciclovir were superior in treating recurrent herpes labialis. Ethosomal patches also delivered testosterone more effectively than commercial patches and showed potential for antiparkinsonian treatment with trihexyphenidyl hydrochloride. Additionally, ethosomal delivery of insulin in rats resulted in sustained lower blood glucose levels for at least 8 hours.
