Efficacy and Safety of Low-Dose Oral Minoxidil in the Management of Androgenetic Alopecia

    January 2024 in “ Expert Opinion on Pharmacotherapy ”
    Aditya K. Gupta, Mesbah Talukder, Avner Shemer
    Studysummary This source suggests that oral minoxidil could be a safe and effective treatment option for both female and male androgenetic alopecia, although it is currently used off-label.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on tandfonline.com →
    Discuss this study in the Community →

    Research cited in this study 55

    1. Blood Pressure Monitoring for Minoxidil Therapy in Alopecia Patients SKIN The Journal of Cutaneous Medicine · 2023
    2. Low Dose Oral Minoxidil as Monotherapy in Patients With Hair Loss Journal of The American Academy of Dermatology · 2023
    3. Low-Dose Oral Minoxidil for Alopecia: A Single-Center Retrospective Review Journal of The American Academy of Dermatology · 2023
    4. Safety and Tolerability of Low Dose Oral Minoxidil Monotherapy in Female Pattern Hair Loss: A Retrospective Review With Longitudinal Ambulatory Blood Pressure Monitoring JAAD International · 2023
    5. Retrospective Review of Oral and Topical Minoxidil for Cancer Treatment-Induced Hair Loss Archives of Dermatological Research · 2023
    6. Low-Dose Oral Minoxidil Improves Hair Density in Traction Alopecia Journal of The American Academy of Dermatology · 2023
    7. Efficacy of Low-Dose Oral Minoxidil in the Management of Anticancer Therapy-Induced Alopecia in Patients With Breast Cancer: A Retrospective Cohort Study Journal of The American Academy of Dermatology · 2022
    8. Systemic Minoxidil for Hair Disorders in Pediatric Patients: A Safety and Tolerability Review International Journal of Dermatology · 2022
    9. Pericardial, Pleural Effusion and Anasarca: A Rare Complication of Low-Dose Oral Minoxidil for Hair Loss JAAD case reports · 2022
    10. The State-of-the-Art in the Management of Androgenetic Alopecia: A Review of New Therapies and Treatment Algorithms JEADV Clinical Practice · 2022
    11. Prospective Cardiovascular Evaluation with 24-Hour Holter and Ambulatory Blood Pressure Monitoring in Men Using 5-mg Oral Minoxidil for Androgenetic Alopecia Journal of The American Academy of Dermatology · 2022
    12. Low-Dose Oral Minoxidil for Treatment of Androgenetic Alopecia and Telogen Effluvium in a Pediatric Population: A Descriptive Study Journal of The American Academy of Dermatology · 2022
    13. Serious Adverse Effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment Actas Dermo-Sifiliográficas · 2022
    14. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    15. Randomized Clinical Trial of Low-Dose Oral Minoxidil for the Treatment of Female Pattern Hair Loss: 0.25 mg Versus 1 mg Journal of The American Academy of Dermatology · 2022
    16. There Is a Positive Dose-Dependent Association Between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings From a Systematic Review With Meta-Regression Analyses Skin appendage disorders · 2022
    17. Low-Dose Oral Minoxidil Increases Hair Density and Thickness in Androgenetic Alopecia: A Retrospective Analysis of 60 Patients Journal of The European Academy of Dermatology and Venereology · 2021
    18. Retinal Artery Occlusion as a Probable Idiosyncratic Reaction to Topical Minoxidil: A Case Report Journal of Medical Case Reports · 2021
    19. A Randomized Clinical Trial on Therapeutic Effects of 0.25 mg Oral Minoxidil Tablets on Treatment of Female Pattern Hair Loss Dermatologic Therapy · 2021
    20. SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth Journal of Cosmetic Dermatology · 2021
    21. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    22. Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2020
    23. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    24. Characterization and Management of Hypertrichosis Induced by Low-Dose Oral Minoxidil in the Treatment of Hair Loss Journal of The American Academy of Dermatology · 2020
    25. Efficacy and Safety of Oral Minoxidil in Female Androgenetic Alopecia Dermatologic Therapy · 2020
    26. Safety of Low-Dose Oral Minoxidil Treatment for Hair Loss: A Systematic Review and Pooled Analysis of Individual Patient Data Dermatologic Therapy · 2020
    27. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    28. Minoxidil Sulfotransferase Enzyme (SULT1A1) Genetic Variants Predict Response to Oral Minoxidil Treatment for Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2020
    29. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Cells · 2020
    30. Novel Topical Booster Enhances Follicular Sulfotransferase Activity in Patients with Androgenetic Alopecia: A New Strategy to Improve Minoxidil Response Journal of The European Academy of Dermatology and Venereology · 2020
    31. Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris Journal of The American Academy of Dermatology · 2020
    32. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    33. Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients Dermatologic Therapy · 2019
    34. Very-Low-Dose Oral Minoxidil in Male Androgenetic Alopecia: A Study with Quantitative Trichoscopic Documentation Journal of The American Academy of Dermatology · 2019
    35. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    36. Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2019
    37. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    38. Effectiveness and Safety of Low-Dose Oral Minoxidil in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2019
    39. Loose Anagen Hair Syndrome: Treatment with Systemic Minoxidil Characterized by Marked Hair Color Change Australasian Journal of Dermatology · 2018
    40. Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells International Journal of Trichology · 2018
    41. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    42. Treatment of Monilethrix with Oral Minoxidil JAAD case reports · 2016
    43. Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect Journal of Dermatological Science · 2011
    44. Medical Treatments for Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2008
    45. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    46. Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp Journal of Dermatological Science · 1999
    47. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    48. The Pharmacokinetics of 2.5- to 10-mg Oral Doses of Minoxidil in Healthy Volunteers The Journal of Clinical Pharmacology · 1989
    49. Selective Inhibition by Minoxidil of Prostacyclin Production by Cells in Culture Biochemical Pharmacology · 1988
    50. Evaluation of Oral Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1987
    51. Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster Archives of Dermatology · 1987
    52. In Vitro Suppression of Human Lymphocyte Activity by Minoxidil International Journal of Dermatology · 1985
    53. Minoxidil and Pericardial Effusion: An Idiosyncratic Reaction Clinical Pharmacology & Therapeutics · 1981
    54. Pharmacology and Pharmacokinetics of Minoxidil Journal of Cardiovascular Pharmacology · 1980
    55. Pericardial Disorders During Open-Label Study of 1,869 Severely Hypertensive Patients Treated with Minoxidil Journal of Cardiovascular Pharmacology · 1980

    Related research 7

    1. Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2023
    2. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    3. The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years Italian journal of dermatology and venereology · 2018
    4. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    5. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    6. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    7. Topical Minoxidil Therapy and Hair Regrowth Archives of Dermatology · 1985