A Randomized Clinical Trial on Therapeutic Effects of 0.25 mg Oral Minoxidil Tablets on Treatment of Female Pattern Hair Loss

    September 2021 in “ Dermatologic Therapy ”
    Sadegh Vahabi-Amlashi, Pouran Layegh, Bita Kiafar, Masoumeh Hoseininezhad, Mohammadreza Abbaspour, Saeedeh Hajebi Khaniki, Mehdi Forouzanfar, Vahideh Sabeti
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    Studysummary In this triple-blind randomized clinical trial, researchers found that oral minoxidil 0.25 mg tablets were as effective as 2% topical minoxidil for increasing hair diameter and density in women with female pattern hair loss, with similarly minor side effects. Our plain-language summary of this paper — not a Tressless recommendation.
    This randomized clinical trial evaluated the therapeutic effects of 0.25 mg oral minoxidil tablets on female pattern hair loss (FPHL) in 72 women over 9 months. Group 1 received oral minoxidil and a topical placebo, while Group 2 received topical minoxidil and an oral placebo. Both groups showed significant improvements in hair diameter and density, with Group 1 increasing from 0.044 mm to 0.048 mm and 102/cm² to 115/cm², and Group 2 from 0.044 mm to 0.047 mm and 107/cm² to 113/cm². The differences between the groups were not statistically significant (p = 0.077 for hair diameter and p = 0.674 for hair density). Side effects were minimal. The study concluded that oral minoxidil is an effective alternative treatment for FPHL, particularly for patients who have poor compliance with topical minoxidil.
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