SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth

June 2021 in “ Journal of Cosmetic Dermatology ”

Rachita Dhurat, Sanober Burzin Daruwalla, Suraj Pai, Maja Kovacevic, John D. McCoy, Jerry Shapiro, Rod Sinclair, Sergio Vano-Galvan, Andy Goren

SULT1A1 minoxidil topical minoxidil hair regrowth hair loss enzyme booster Minoxidil Sulfotransferase Rogaine

TLDR Enzyme booster SULT1A1 greatly enhances hair regrowth with minoxidil.

A study involving multiple doctors and medical centers from around the world found that using an enzyme booster called SULT1A1 along with topical minoxidil significantly improved hair regrowth in individuals with hair loss. Boosting the SULT1A1 enzyme, responsible for metabolizing minoxidil, significantly improves the response to topical minoxidil for hair regrowth. Minoxidil is the only topical drug approved by the US FDA to regrow hair, but has a low efficacy rate, with only approximately 35% of subjects regrowing hair after 16 weeks of use in clinical trials. The study was not funded and study materials were provided at no cost by Applied Biology, Inc.

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SULT1A1 (Minoxidil Sulfotransferase) Enzyme Booster Significantly Improves Response to Topical Minoxidil for Hair Regrowth

Research cited in this study

research Novel 'After Minoxidil' Spray Improves Topical Minoxidil Compliance and Hair Style Manageability

research Minoxidil Sulfotransferase Enzyme (SULT1A1) Genetic Variants Predict Response to Oral Minoxidil Treatment for Female Pattern Hair Loss

research Novel Topical Booster Enhances Follicular Sulfotransferase Activity in Patients with Androgenetic Alopecia: A New Strategy to Improve Minoxidil Response

research Characterization of Follicular Minoxidil Sulfotransferase Activity in a Cohort of Pattern Hair Loss Patients from the Indian Subcontinent

research Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

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