TLDR Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
This study from 31 years ago investigated the nature of minoxidil sulfotransferase activity in epithelial tissue and found that it is a marker of keratinocyte differentiation and distinct from cholesterol sulfotransferase. The study suggests that minoxidil sulfotransferase may play a role in hair growth. The researchers also found that the differentiation process is marked by the induction of a second sulfotransferase that results in the sulfation of minoxidil, but the relevance of this sulfotransferase remains to be determined.
46 citations,
January 1991 in “Journal of Investigative Dermatology” Minoxidil works in liver and outer hair root sheath for hair growth.
166 citations,
November 1990 in “Journal of Investigative Dermatology” Minoxidil sulfate stimulates hair growth.
68 citations,
September 1990 in “Biochemical Pharmacology” Minoxidil activates hair growth by being sulfated by P-PST in the human liver.
39 citations,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
59 citations,
February 1998 in “Chemico-Biological Interactions” Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.
16 citations,
May 1992 in “Journal of Investigative Dermatology” Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
39 citations,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
66 citations,
September 1982 in “Biochemical Pharmacology” Liver enzyme helps minoxidil work better for blood vessel relaxation.
