TLDR Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
This study from 31 years ago investigated the nature of minoxidil sulfotransferase activity in epithelial tissue and found that it is a marker of keratinocyte differentiation and distinct from cholesterol sulfotransferase. The study suggests that minoxidil sulfotransferase may play a role in hair growth. The researchers also found that the differentiation process is marked by the induction of a second sulfotransferase that results in the sulfation of minoxidil, but the relevance of this sulfotransferase remains to be determined.
Cited in this study
4 / 4 results
46 citations
,
January 1991 in “Journal of Investigative Dermatology” Minoxidil works in liver and outer hair root sheath for hair growth.
166 citations
,
November 1990 in “Journal of Investigative Dermatology” Minoxidil sulfate stimulates hair growth.
68 citations
,
September 1990 in “Biochemical Pharmacology” Minoxidil activates hair growth by being sulfated by P-PST in the human liver.
39 citations
,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
59 citations
,
February 1998 in “Chemico-Biological Interactions” Minoxidil breakdown varies by enzymes, affecting hair loss treatment effectiveness.
16 citations
,
May 1992 in “Journal of Investigative Dermatology” Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
39 citations
,
November 1987 in “Clinica Chimica Acta” Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.
66 citations
,
September 1982 in “Biochemical Pharmacology” Liver enzyme helps minoxidil work better for blood vessel relaxation.