Minoxidil Sulfotransferase, A Marker Of Human Keratinocyte Differentiation

    May 1992 in “ Journal of Investigative Dermatology ”
    Garland A. Johnson, Carolyn D. Baker, Karen Knight
    Image of study
    TLDR Minoxidil sulfotransferase is a marker of keratinocyte differentiation and may play a role in hair growth.
    This study from 31 years ago investigated the nature of minoxidil sulfotransferase activity in epithelial tissue and found that it is a marker of keratinocyte differentiation and distinct from cholesterol sulfotransferase. The study suggests that minoxidil sulfotransferase may play a role in hair growth. The researchers also found that the differentiation process is marked by the induction of a second sulfotransferase that results in the sulfation of minoxidil, but the relevance of this sulfotransferase remains to be determined.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  52 upvotes 3 months ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community Painkillers May Block Minoxidil

      in Research/Science  15 upvotes 2 weeks ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 month ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 5 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community Comprehensive Microneedling Guide

      in Microneedling  291 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Minoxidil Sulfate makes everyone a responder

      in Research/Science  259 upvotes 4 months ago
      Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

    Related Research

    4 / 4 results