The State-of-the-Art in the Management of Androgenetic Alopecia: A Review of New Therapies and Treatment Algorithms

    July 2022 in “ JEADV Clinical Practice
    Miguel Dominguez-Santas, Borja Diaz-Guimaraens, David Saceda-Corralo, Angela Hermosa‐Gelbard, Oscar M. Moreno-Arrones, Cristina Pindado-Ortega, Diego Fernandez-Nieto, Juan Jimenez-Cauhe, Daniel Ortega-Quijano, Ana Suarez-Valle, Pedro Jaén-Olasolo, Sergio Vano-Galvan
    TLDR New and existing treatments for hair loss show promise, with some being more effective for men and others for women.
    The review highlights advancements in managing androgenetic alopecia (AGA) with both established and emerging therapies. Oral finasteride and topical minoxidil remain FDA-approved treatments, while low-dose oral minoxidil (LDOM) and dutasteride show promising results, particularly in male pattern hair loss (MPHL). For female pattern hair loss (FPHL), higher doses of finasteride and dutasteride are effective, though contraindicated in pregnancy. New therapies like oral contraceptives, spironolactone, bicalutamide, and mesotherapy with dutasteride show varying degrees of success. Platelet-rich plasma (PRP) therapy and other novel treatments like botulinum toxin and low-level light therapy (LLLT) also demonstrate potential. Investigational drugs such as pyrilutamide and SAMiRNA-AR68 are in advanced trial phases, while setipiprant and HMI-115 are in earlier stages. The review underscores the need for dermatologists to stay updated on these evolving treatment options.
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      community I have tried many treatments but it's getting worse. 23M.

      in Treatment  86 upvotes 3 months ago
      A 23-year-old male experiencing worsening hair loss has tried topical Minoxidil, Finasteride, Progesterone, Hydrocortisone butyrate, and Ketoconazole. He is considering switching to oral Finasteride due to concerns about side effects and lack of improvement.

      community Maintaining hair until Breezula without Fin

      in Treatment  6 upvotes 4 years ago
      A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

      community Is microneedling + minoxidil better than oral minoxidil

      in Chat  29 upvotes 6 months ago
      Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

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